Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the surface antibacterial activity and biocompatibility of titanium implants. A TNWs film was produced on a Ti substrate by an alkali hydrothermal re...

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Published inACS applied materials & interfaces Vol. 8; no. 26; pp. 16584 - 16594
Main Authors Xu, Ziqiang, Li, Man, Li, Xia, Liu, Xiangmei, Ma, Fei, Wu, Shuilin, Yeung, K. W. K, Han, Yong, Chu, Paul K
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 06.07.2016
Subjects
Animals
Anti-Bacterial Agents - pharmacology
antibacterial properties
Bacteria - drug effects
biocompatibility
Cell Line
Cell Survival - drug effects
cell viability
chemical reduction
chitosan
Chitosan - chemistry
Mice
nanosilver
nanowires
Nanowires - chemistry
Nanowires - toxicity
Prostheses and Implants - microbiology
silver
Silver - pharmacology
silver nitrate
titanium
Titanium - pharmacology
ultraviolet radiation
Ag nanoparticle
antibacterial
nanostructured film
implant
titanium
nanowire
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Abstract A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the surface antibacterial activity and biocompatibility of titanium implants. A TNWs film was produced on a Ti substrate by an alkali hydrothermal reaction and subsequently doped by Ag nanoparticles through an ultraviolet light chemical reduction. The CS nanofilm was deposited on the Ag nanoparticles through a spin-assisted layer by layer assembly method. The results disclosed that Ag nanoparticles were successfully carried by TNWs and homogeneously distributed on the entire surface. Moreover, a CS nanofilm was also successfully deposited on the Ag nanoparticles. Antibacterial tests showed that the samples modified with a higher initial concentration of AgNO3 solution exhibited better antibacterial activity, and that a CS nanofilm could further improve the antibacterial activity of the TNWs. Cell viability and ALP tests revealed that the release of Ag+ was detrimental for the growth, proliferation, and differentiation of MC3T3, and that CS could lower the negative effects of Ag gradually as the incubation time increased.
AbstractList A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the surface antibacterial activity and biocompatibility of titanium implants. A TNWs film was produced on a Ti substrate by an alkali hydrothermal reaction and subsequently doped by Ag nanoparticles through an ultraviolet light chemical reduction. The CS nanofilm was deposited on the Ag nanoparticles through a spin-assisted layer by layer assembly method. The results disclosed that Ag nanoparticles were successfully carried by TNWs and homogeneously distributed on the entire surface. Moreover, a CS nanofilm was also successfully deposited on the Ag nanoparticles. Antibacterial tests showed that the samples modified with a higher initial concentration of AgNO₃ solution exhibited better antibacterial activity, and that a CS nanofilm could further improve the antibacterial activity of the TNWs. Cell viability and ALP tests revealed that the release of Ag⁺ was detrimental for the growth, proliferation, and differentiation of MC3T3, and that CS could lower the negative effects of Ag gradually as the incubation time increased.
A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the surface antibacterial activity and biocompatibility of titanium implants. A TNWs film was produced on a Ti substrate by an alkali hydrothermal reaction and subsequently doped by Ag nanoparticles through an ultraviolet light chemical reduction. The CS nanofilm was deposited on the Ag nanoparticles through a spin-assisted layer by layer assembly method. The results disclosed that Ag nanoparticles were successfully carried by TNWs and homogeneously distributed on the entire surface. Moreover, a CS nanofilm was also successfully deposited on the Ag nanoparticles. Antibacterial tests showed that the samples modified with a higher initial concentration of AgNO3 solution exhibited better antibacterial activity, and that a CS nanofilm could further improve the antibacterial activity of the TNWs. Cell viability and ALP tests revealed that the release of Ag+ was detrimental for the growth, proliferation, and differentiation of MC3T3, and that CS could lower the negative effects of Ag gradually as the incubation time increased.
A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the surface antibacterial activity and biocompatibility of titanium implants. A TNWs film was produced on a Ti substrate by an alkali hydrothermal reaction and subsequently doped by Ag nanoparticles through an ultraviolet light chemical reduction. The CS nanofilm was deposited on the Ag nanoparticles through a spin-assisted layer by layer assembly method. The results disclosed that Ag nanoparticles were successfully carried by TNWs and homogeneously distributed on the entire surface. Moreover, a CS nanofilm was also successfully deposited on the Ag nanoparticles. Antibacterial tests showed that the samples modified with a higher initial concentration of AgNO3 solution exhibited better antibacterial activity, and that a CS nanofilm could further improve the antibacterial activity of the TNWs. Cell viability and ALP tests revealed that the release of Ag(+) was detrimental for the growth, proliferation, and differentiation of MC3T3, and that CS could lower the negative effects of Ag gradually as the incubation time increased.A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the surface antibacterial activity and biocompatibility of titanium implants. A TNWs film was produced on a Ti substrate by an alkali hydrothermal reaction and subsequently doped by Ag nanoparticles through an ultraviolet light chemical reduction. The CS nanofilm was deposited on the Ag nanoparticles through a spin-assisted layer by layer assembly method. The results disclosed that Ag nanoparticles were successfully carried by TNWs and homogeneously distributed on the entire surface. Moreover, a CS nanofilm was also successfully deposited on the Ag nanoparticles. Antibacterial tests showed that the samples modified with a higher initial concentration of AgNO3 solution exhibited better antibacterial activity, and that a CS nanofilm could further improve the antibacterial activity of the TNWs. Cell viability and ALP tests revealed that the release of Ag(+) was detrimental for the growth, proliferation, and differentiation of MC3T3, and that CS could lower the negative effects of Ag gradually as the incubation time increased.
Author Ma, Fei
Liu, Xiangmei
Chu, Paul K
Wu, Shuilin
Han, Yong
Li, Man
Xu, Ziqiang
Li, Xia
Yeung, K. W. K
AuthorAffiliation The University of Hong Kong
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering
Hubei University
Division of Spine Surgery, Department of Orthopaedics & Traumatology, Li KaShing Faculty of Medicine
Department of Physics & Materials Science
City University of Hong Kong
State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering
Xi’an Jiaotong University
AuthorAffiliation_xml – name: Xi’an Jiaotong University
– name: Division of Spine Surgery, Department of Orthopaedics & Traumatology, Li KaShing Faculty of Medicine
– name: State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering
– name: City University of Hong Kong
– name: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering
– name: Department of Physics & Materials Science
– name: The University of Hong Kong
– name: Hubei University
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  fullname: Xu, Ziqiang
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/27336202$$D View this record in MEDLINE/PubMed
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Keywords Ag nanoparticle
antibacterial
nanostructured film
implant
titanium
nanowire
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Snippet A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the...
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SubjectTerms Animals
Anti-Bacterial Agents - pharmacology
antibacterial properties
Bacteria - drug effects
biocompatibility
Cell Line
Cell Survival - drug effects
cell viability
chemical reduction
chitosan
Chitosan - chemistry
Mice
nanosilver
nanowires
Nanowires - chemistry
Nanowires - toxicity
Prostheses and Implants - microbiology
silver
Silver - pharmacology
silver nitrate
titanium
Titanium - pharmacology
ultraviolet radiation
Title Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants
URI http://dx.doi.org/10.1021/acsami.6b04161
https://www.ncbi.nlm.nih.gov/pubmed/27336202
https://www.proquest.com/docview/1802476229
https://www.proquest.com/docview/2000335410
Volume 8
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