Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects

• Published in: Molecular pharmaceutics Vol. 13; no. 8; pp. 2631 - 2640
• Main Authors: Miyauchi, Eisuke, Tachikawa, Masanori, Declèves, Xavier, Uchida, Yasuo, Bouillot, Jean-Luc, Poitou, Christine, Oppert, Jean-Michel, Mouly, Stéphane, Bergmann, Jean-François, Terasaki, Tetsuya, Scherrmann, Jean-Michel, Lloret-Linares, Célia
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.08.2016
• Subjects: ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism; Cytochrome P-450 CYP2C9 - metabolism; Cytochrome P-450 CYP2D6 - metabolism; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 Enzyme System - metabolism; Female; Glucose Transporter Type 2 - metabolism; Glucose Transporter Type 5 - metabolism; Glucuronosyltransferase - metabolism; Humans; In Vitro Techniques; Intestine, Small - metabolism; Jejunum - metabolism; Male; Minor Histocompatibility Antigens - metabolism; Neoplasm Proteins - metabolism; Obesity, Morbid - metabolism; Organic Anion Transporters - metabolism; Peptide Transporter 1; Sodium-Glucose Transporter 1 - metabolism; Symporters; morbid obesity; transporter; UGT2B17; small intestine; CYP; BCRP/ABCG2; drug-metabolizing enzymes; OATP2B1

Protein expression levels of drug-metabolizing enzymes and transporters in human jejunal tissues excised from morbidly obese subjects during gastric bypass surgery were evaluated using quantitative targeted absolute proteomics. Protein expression levels of 15 cytochrome P450 (CYP) enzymes, 10 UDP-gl...