Effect of the Conjugation Density of Triphenylphosphonium Cation on the Mitochondrial Targeting of Poly(amidoamine) Dendrimers

• Published in: Molecular pharmaceutics Vol. 12; no. 8; pp. 3043 - 3053
• Main Authors: Bielski, Elizabeth R, Zhong, Qian, Brown, Matthew, da Rocha, Sandro R. P
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 03.08.2015
• Subjects: Apoptosis - drug effects; Dendrimers - pharmacology; Drug Carriers - chemistry; Drug Delivery Systems; Humans; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Mitochondria - drug effects; Mitochondria - pathology; Organophosphorus Compounds - chemistry; Polyamines - pharmacology; Polyethylene Glycols - chemistry; Tumor Cells, Cultured; PAMAM dendrimers; polyethylene glycol; PEG; triphenylphosphonium cation; TPP; drug delivery; mitochondrial targeting

Many clinically relevant diseases with known poor therapeutic outcomes, including cancer and neurodegenerative disorders, have been directly linked to mitochondrial dysfunction. The ability to efficiently target therapeutics to intracellular organelles such as mitochondria may represent new opportun...