Biodegradable Polymer-Coated Multifunctional Graphene Quantum Dots for Light-Triggered Synergetic Therapy of Pancreatic Cancer

In this work, we reported the synthesis of an engineered novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer (MiaPaCa-2 cells) therapy applications. Such a nanocarrier was utilized to co-load doxorubicin (DOX) and small...

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Published inACS applied materials & interfaces Vol. 11; no. 3; pp. 2768 - 2781
Main Authors Yang, Chengbin, Chan, Kok Ken, Xu, Gaixia, Yin, Mingjie, Lin, Guimiao, Wang, Xiaomei, Lin, Wei-Jen, Birowosuto, Muhammad Danang, Zeng, Shuwen, Ogi, Takashi, Okuyama, Kikuo, Permatasari, Fitri Aulia, Iskandar, Ferry, Chen, Chih-Kuang, Yong, Ken-Tye
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 23.01.2019
Subjects
antineoplastic activity
biodegradability
Biodegradable Plastics - chemistry
Biodegradable Plastics - therapeutic use
Cell Survival - drug effects
doxorubicin
Doxorubicin - chemistry
Doxorubicin - pharmacology
graphene
Graphite - chemistry
Graphite - therapeutic use
heat
Humans
in vivo studies
Light
nanocarriers
Nanoparticles - chemistry
pancreatic neoplasms
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - therapy
Phototherapy
polyesters
Polymers - chemistry
quantum dots
Quantum Dots - chemistry
Quantum Dots - therapeutic use
small interfering RNA
BCPV
pancreatic cancer
light-triggered
siRNA
DOX
graphene quantum dots
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Abstract In this work, we reported the synthesis of an engineered novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer (MiaPaCa-2 cells) therapy applications. Such a nanocarrier was utilized to co-load doxorubicin (DOX) and small interfering ribonucleic acid (siRNA), resulting in the formation of GQD/DOX/BCPV/siRNA nanocomplexes. The resulting nanocomplexes have demonstrated high stability in physiologically mimicking media, excellent K-ras downregulation activity, and effective bioactivity inhibition for MiaPaCa-2 cells. More importantly, laser light was used to generate heat for the nanocomplexes via the photothermal effect to damage the cells, which was further employed to trigger the release of payloads from the nanocomplexes. Such triggered release function greatly enhanced the anticancer activity of the nanocomplexes. Preliminary colony formation study also suggested that GQD/DOX/BCPV/siRNA nanocomplexes are qualified carrier candidates in subsequent in vivo tests.
AbstractList In this work, we reported the synthesis of an engineered novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer (MiaPaCa-2 cells) therapy applications. Such a nanocarrier was utilized to co-load doxorubicin (DOX) and small interfering ribonucleic acid (siRNA), resulting in the formation of GQD/DOX/BCPV/siRNA nanocomplexes. The resulting nanocomplexes have demonstrated high stability in physiologically mimicking media, excellent K-ras downregulation activity, and effective bioactivity inhibition for MiaPaCa-2 cells. More importantly, laser light was used to generate heat for the nanocomplexes via the photothermal effect to damage the cells, which was further employed to trigger the release of payloads from the nanocomplexes. Such triggered release function greatly enhanced the anticancer activity of the nanocomplexes. Preliminary colony formation study also suggested that GQD/DOX/BCPV/siRNA nanocomplexes are qualified carrier candidates in subsequent in vivo tests.
In this work, we reported the synthesis of an engineered novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer (MiaPaCa-2 cells) therapy applications. Such a nanocarrier was utilized to co-load doxorubicin (DOX) and small interfering ribonucleic acid (siRNA), resulting in the formation of GQD/DOX/BCPV/siRNA nanocomplexes. The resulting nanocomplexes have demonstrated high stability in physiologically mimicking media, excellent K-ras downregulation activity, and effective bioactivity inhibition for MiaPaCa-2 cells. More importantly, laser light was used to generate heat for the nanocomplexes via the photothermal effect to damage the cells, which was further employed to trigger the release of payloads from the nanocomplexes. Such triggered release function greatly enhanced the anticancer activity of the nanocomplexes. Preliminary colony formation study also suggested that GQD/DOX/BCPV/siRNA nanocomplexes are qualified carrier candidates in subsequent in vivo tests.In this work, we reported the synthesis of an engineered novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer (MiaPaCa-2 cells) therapy applications. Such a nanocarrier was utilized to co-load doxorubicin (DOX) and small interfering ribonucleic acid (siRNA), resulting in the formation of GQD/DOX/BCPV/siRNA nanocomplexes. The resulting nanocomplexes have demonstrated high stability in physiologically mimicking media, excellent K-ras downregulation activity, and effective bioactivity inhibition for MiaPaCa-2 cells. More importantly, laser light was used to generate heat for the nanocomplexes via the photothermal effect to damage the cells, which was further employed to trigger the release of payloads from the nanocomplexes. Such triggered release function greatly enhanced the anticancer activity of the nanocomplexes. Preliminary colony formation study also suggested that GQD/DOX/BCPV/siRNA nanocomplexes are qualified carrier candidates in subsequent in vivo tests.
Author Xu, Gaixia
Birowosuto, Muhammad Danang
Permatasari, Fitri Aulia
Lin, Wei-Jen
Zeng, Shuwen
Yin, Mingjie
Ogi, Takashi
Chen, Chih-Kuang
Chan, Kok Ken
Yang, Chengbin
Wang, Xiaomei
Okuyama, Kikuo
Iskandar, Ferry
Yong, Ken-Tye
Lin, Guimiao
AuthorAffiliation Department of Fiber and Composite Materials
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Sciences Center
School of Electrical and Electronic Engineering
Department of Physics, Faculty of Mathematics and Natural Sciences
Hiroshima University
Department of Chemical and Materials Engineering
CINTRA CNRS/NTU/THALES UMI 3288
Department of Physiology, School of Basic Medical Sciences, Health Sciences Center
Department of Chemical Engineering, Graduate School of Engineering
AuthorAffiliation_xml – name: Department of Chemical and Materials Engineering
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– name: Department of Physics, Faculty of Mathematics and Natural Sciences
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  organization: School of Electrical and Electronic Engineering
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30589254$$D View this record in MEDLINE/PubMed
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light-triggered
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Snippet In this work, we reported the synthesis of an engineered novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum...
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SubjectTerms antineoplastic activity
biodegradability
Biodegradable Plastics - chemistry
Biodegradable Plastics - therapeutic use
Cell Survival - drug effects
doxorubicin
Doxorubicin - chemistry
Doxorubicin - pharmacology
graphene
Graphite - chemistry
Graphite - therapeutic use
heat
Humans
in vivo studies
Light
nanocarriers
Nanoparticles - chemistry
pancreatic neoplasms
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - therapy
Phototherapy
polyesters
Polymers - chemistry
quantum dots
Quantum Dots - chemistry
Quantum Dots - therapeutic use
small interfering RNA
Title Biodegradable Polymer-Coated Multifunctional Graphene Quantum Dots for Light-Triggered Synergetic Therapy of Pancreatic Cancer
URI http://dx.doi.org/10.1021/acsami.8b16168
https://www.ncbi.nlm.nih.gov/pubmed/30589254
https://www.proquest.com/docview/2161065314
https://www.proquest.com/docview/2189556343
Volume 11
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