Skin Delivery of Hydrophilic Biomacromolecules Using Marine Sponge Spicules

• Published in: Molecular pharmaceutics Vol. 14; no. 9; pp. 3188 - 3200
• Main Authors: Zhang, Saiman, Ou, Huilong, Liu, Chunyun, Zhang, Yuan, Mitragotri, Samir, Wang, Dexiang, Chen, Ming
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 05.09.2017
• Subjects: Animals; Epidermis - metabolism; Female; Guinea Pigs; Haliclona - metabolism; Hydrophobic and Hydrophilic Interactions; Mice, Inbred BALB C; Microscopy, Confocal; Microscopy, Electron, Scanning; Molecular Weight; Skin - metabolism; Skin Absorption; Water - metabolism; hydrophilic biomacromolecules; topical microneedles; spicules

We report the development of sponge Haliclona sp. spicules, referred to as SHS, and its topical application in skin delivery of hydrophilic biomacromolecules, a series of fluorescein isothiocyanate-dextrans (FDs). SHS are silicious oxeas which are sharp-edged and rod-shaped (∼120 μm in length and ∼7...