Shape-Dependent Radiosensitization Effect of Gold Nanostructures in Cancer Radiotherapy: Comparison of Gold Nanoparticles, Nanospikes, and Nanorods

• Published in: ACS applied materials & interfaces Vol. 9; no. 15; pp. 13037 - 13048
• Main Authors: Ma, Ningning, Wu, Fu-Gen, Zhang, Xiaodong, Jiang, Yao-Wen, Jia, Hao-Ran, Wang, Hong-Yin, Li, Yan-Hong, Liu, Peidang, Gu, Ning, Chen, Zhan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.04.2017
• Subjects: cell cycle; Gold; irradiation; Metal Nanoparticles; nanogold; nanorods; Nanostructures; Nanotubes; neoplasm cells; neoplasms; polyethylene glycol; radiotherapy; X-radiation; X-Rays; radiosensitizing effect; X-ray radiotherapy; shape-dependent; gold nanostructures; anticancer

The shape effect of gold (Au) nanomaterials on the efficiency of cancer radiotherapy has not been fully elucidated. To address this issue, Au nanomaterials with different shapes but similar average size (∼50 nm) including spherical gold nanoparticles (GNPs), gold nanospikes (GNSs), and gold nanorods...