Acid-Triggered Nanoexpansion Polymeric Micelles for Enhanced Photodynamic Therapy

• Published in: ACS applied materials & interfaces Vol. 11; no. 37; pp. 33697 - 33705
• Main Authors: Zhong, Sheng, Chen, Chao, Yang, Guoliang, Zhu, Yucheng, Cao, Hongliang, Xu, Beijian, Luo, Yaoqin, Gao, Yun, Zhang, Weian
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 18.09.2019
• Subjects: Animals; biocompatibility; composite polymers; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - pharmacokinetics; Delayed-Action Preparations - pharmacology; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; hydrolysis; hydrophilicity; hydrophobicity; in vivo studies; irradiation; Mice; Micelles; moieties; Nanoparticles - chemistry; Nanoparticles - therapeutic use; neoplasms; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - metabolism; Neoplasms, Experimental - pathology; oxygen; Photochemotherapy; photosensitizing agents; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; polymerization; precision medicine; singlet oxygen; Tumor Microenvironment; Xenograft Model Antitumor Assays; acid-triggered nanoexpansion; porphyrin; aggregation caused quenching (ACQ); RAFT polymerization; photodynamic therapy

Photodynamic therapy (PDT) as a noninvasive and selective treatment technology has presented great potential in cancer prevention and precision medicine, but its therapeutic efficacy is still greatly inhibited by the limitations of photosensitizers (PSs) in the microenvironment such as the aggregati...