Clinical Correlates and Familial Aggregation of Age at Onset in Bipolar Disorder

• Published in: The American journal of psychiatry Vol. 163; no. 2; pp. 240 - 246
• Main Authors: Lin, Ping-I, McInnis, Melvin G., Potash, James B., Willour, Virginia, MacKinnon, Dean F., DePaulo, J. Raymond, Zandi, Peter P.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.02.2006; American Psychiatric Association
• Subjects: Adult; Adult and adolescent clinical studies; Age; Age Factors; Age of Onset; Analysis of Variance; Behavioral sciences; Biological and medical sciences; Bipolar disorder; Bipolar Disorder - diagnosis; Bipolar Disorder - epidemiology; Bipolar Disorder - genetics; Bipolar disorders; Comorbidity; Confidence Intervals; Diagnosis, Dual (Psychiatry); Epoxy Compounds; Family; Family Health; Female; Genetic Heterogeneity; Genotype & phenotype; Heterocyclic Compounds, 4 or More Rings; Humans; Illnesses; Logistic Models; Male; Medical sciences; Mental disorders; Middle Aged; Mood disorders; Normal Distribution; Odds Ratio; Pedigree; Psychiatric Status Rating Scales - statistics & numerical data; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Studies; Substance-Related Disorders - diagnosis; Substance-Related Disorders - epidemiology; Substance-Related Disorders - genetics; Suicides & suicide attempts; Mood disorder; Aggregation; Bipolar disorder; Age of onset

OBJECTIVE: To assess whether age at onset variation reflects underlying genetic heterogeneity in bipolar disorder, the authors examined the clinical and familial characteristics of age at onset in bipolar disorder subjects from families with multiple affected members. METHOD: A total of 211 families...