Negative Signs and Symptoms Secondary to Antipsychotics: A Double-Blind, Randomized Trial of a Single Dose of Placebo, Haloperidol, and Risperidone in Healthy Volunteers

• Published in: The American journal of psychiatry Vol. 163; no. 3; pp. 488 - 493
• Main Authors: Artaloytia, Juan Francisco, Arango, Celso, Lahti, Adrienne, Sanz, Javier, Pascual, Ana, Cubero, Pedro, Prieto, David, Palomo, Tomás
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.03.2006; American Psychiatric Association
• Subjects: Adolescent; Adult; Antipsychotic Agents - adverse effects; Antipsychotic Agents - therapeutic use; Basal Ganglia Diseases - chemically induced; Basal Ganglia Diseases - diagnosis; Basal Ganglia Diseases - epidemiology; Behavioral Symptoms - chemically induced; Behavioral Symptoms - diagnosis; Behavioral Symptoms - epidemiology; Biological and medical sciences; Brief Psychiatric Rating Scale; Clinical trials; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug therapy; Female; Haloperidol - adverse effects; Haloperidol - therapeutic use; Health Status; Hospitals; Humans; Male; Medical sciences; Middle Aged; Neuropharmacology; Patients; Pharmaceutical industry; Pharmacology. Drug treatments; Placebos; Psychiatric Status Rating Scales - statistics & numerical data; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Risperidone - adverse effects; Risperidone - therapeutic use; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - drug therapy; Schizophrenic Psychology; Sleep Stages - drug effects; Surveys and Questionnaires; Atypical antipsychotic; Healthy subject; Neuroleptic; Psychotropic; Dopamine antagonist; Serotonin antagonist; Butyrophenone derivatives; Serotonine receptor; Haloperidol; Psychosis; Chemotherapy; D2 Dopamine receptor; Treatment; Negative symptom; Placebo; Double blind study; Risperidone

OBJECTIVE: Despite the clinical observation that antipsychotics can produce negative symptoms, no previous controlled study, to our knowledge, has evaluated this action in healthy subjects. The present study assessed observer-rated and self-rated negative symptoms produced by conventional and second...