The Leader Peptide Is Not Required for Post-Translational Modification by Lacticin 481 Synthetase

• Published in: Journal of the American Chemical Society Vol. 129; no. 34; pp. 10314 - 10315
• Main Authors: Levengood, Matthew R, Patton, Gregory C, van der Donk, Wilfred A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 29.08.2007
• Subjects: Bacteriocins - biosynthesis; Molecular Sequence Data; Protein Processing, Post-Translational; Protein Sorting Signals; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Lantibiotics are post-translationally modified antimicrobial peptides. The modification process features dehydration of Ser and Thr residues to the corresponding dehydroalanine (Dha) and dehydrobutyrine (Dhb) residues and the subsequent conjugate addition by cysteine thiols onto the dehydro amino ac...