Kinetic Resolution of 2‑Aryl-4-methylenepiperidines toward Enantioenriched Functionalizable Piperidine Fragments
The base n-BuLi with sparteine allows a kinetic resolution of N-Boc-2-aryl-4-methylenepiperidines. The 2,2-disubstituted products and recovered starting materials were isolated with high enantiomeric ratios. From VT-NMR spectroscopy and DFT studies, the rate of rotation of the N-Boc group is fast. L...
Saved in:
Published in | Journal of organic chemistry Vol. 87; no. 13; pp. 8819 - 8823 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
01.07.2022
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Be the first to leave a comment!