Speciation Analysis of Aqueous Nanoparticulate Diclofenac Complexes by Solid-Phase Microextraction

• Published in: Langmuir Vol. 28; no. 41; pp. 14672 - 14680
• Main Authors: Zielińska, Katarzyna, van Leeuwen, Herman P, Thibault, Sylvain, Town, Raewyn M
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 16.10.2012
• Subjects: adsorption; Animals; antiinflammatory drugs; aquatic environment; bovine serum albumin; capillary-electrophoresis; Cattle; Chemistry; Colloidal state and disperse state; desorption; diclofenac; Diclofenac - chemistry; dispersions; drug binding-sites; Exact sciences and technology; General and physical chemistry; mass-spectrometry; metal-complexes; nanoparticles; Nanoparticles - chemistry; nd-spme; Physical and chemical studies. Granulometry. Electrokinetic phenomena; prediction; Serum Albumin, Bovine - chemistry; silica; Silicon Dioxide - chemistry; Solid Phase Microextraction; Surface physical chemistry; Thermodynamics; walled carbon nanotubes; Water - chemistry; water samples; Water; Binary compound; Nanoparticle; Silica; Solid; Thermodynamics; Dynamics; Rate constant; Diffusion; Ungulata; Organic compounds; Partition; Bovine; Prediction; Desorption; Serum albumin; Equilibrium; Dispersion; Sorption; Vertebrata; Mammalia; Adsorption; Silicon oxides; Affinity; Artiodactyla; Solid phase; Interface

The dynamic sorption of an organic compound by nanoparticles (NPs) is analyzed by solid-phase microextraction (SPME) for the example case of the pharmaceutical diclofenac in dispersions of impermeable (silica, SiO2) and permeable (bovine serum albumin, BSA) NPs. It is shown that only the protonated...