Tetrahedral Framework Nucleic Acid Promotes the Treatment of Bisphosphonate-Related Osteonecrosis of the Jaws by Promoting Angiogenesis and M2 Polarization

• Published in: ACS applied materials & interfaces Vol. 12; no. 40; pp. 44508 - 44522
• Main Authors: Zhao, Dan, Cui, Weitong, Liu, Mengting, Li, Jiajie, Sun, Yue, Shi, Sirong, Lin, Shiyu, Lin, Yunfeng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.10.2020
• Subjects: angiogenesis; Animals; bacterial infections; Biological and Medical Applications of Materials and Interfaces; Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy; Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology; Bone Density Conservation Agents - chemical synthesis; Bone Density Conservation Agents - chemistry; Bone Density Conservation Agents - pharmacology; bone metabolism; cell proliferation; Cells, Cultured; Humans; hypercalcemia; immune response; ischemia; macrophages; Macrophages - drug effects; Macrophages - pathology; Male; Mice; Molecular Conformation; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - pathology; nucleic acids; Nucleic Acids - chemical synthesis; Nucleic Acids - chemistry; Nucleic Acids - pharmacology; osteonecrosis; osteoporosis; Particle Size; quality of life; Rats; Rats, Wistar; RAW 264.7 Cells; Surface Properties; toxicity; macrophages; tetrahedral framework nucleic acid; endothelia cells; bisphosphonate-related osteonecrosis of the jaws; angiogenesis; M1/M2 polarization

Bisphosphonates are often used to treat osteoporosis, malignant bone metastases, and hypercalcemia. However, it can cause serious adverse reactions, bisphosphonate-related osteonecrosis of the jaw (BRONJ), which seriously affects the quality of life of patients. At present, the treatment of BRONJ is...