Gastrointestinal Motility Variation and Implications for Plasma Level Variation: Oral Drug Products

• Published in: Molecular pharmaceutics Vol. 13; no. 2; pp. 557 - 567
• Main Authors: Talattof, Arjang, Price, Judy C, Amidon, Gordon L
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.02.2016
• Subjects: Administration, Oral; Anticholesteremic Agents - administration & dosage; Anticholesteremic Agents - blood; Anticholesteremic Agents - pharmacokinetics; Computer Simulation; Diethylcarbamazine - administration & dosage; Diethylcarbamazine - blood; Diethylcarbamazine - pharmacokinetics; Fatty Acids, Monounsaturated - administration & dosage; Fatty Acids, Monounsaturated - blood; Fatty Acids, Monounsaturated - pharmacokinetics; Fluorouracil - administration & dosage; Fluorouracil - blood; Fluorouracil - pharmacokinetics; Gastric Emptying - drug effects; Gastrointestinal Motility - drug effects; Gastrointestinal Transit - drug effects; Humans; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - blood; Immunosuppressive Agents - pharmacokinetics; Indoles - administration & dosage; Indoles - blood; Indoles - pharmacokinetics; Intestinal Absorption - drug effects; Lipoxygenase Inhibitors - administration & dosage; Lipoxygenase Inhibitors - blood; Lipoxygenase Inhibitors - pharmacokinetics; Male; Models, Biological; Tissue Distribution; oral dosage; motility; migrating motor complex; mechanistic physiological model; gastric emptying; bioequivalence; clinical trial simulation

The oral route of administration is still by far the most ubiquitous method of drug delivery. Development in this area still faces many challenges due to the complexity and inhomogeneity of the gastrointestinal environment. In particular, dosing unpredictably relative to motility phase means the gas...