Glucose- and pH-Responsive Nanogated Ensemble Based on Polymeric Network Capped Mesoporous Silica

• Published in: ACS applied materials & interfaces Vol. 7; no. 11; pp. 6310 - 6316
• Main Authors: Tan, Lei, Yang, Mei-Yan, Wu, Hai-Xia, Tang, Zhao-Wen, Xiao, Jian-Yun, Liu, Chuan-Jun, Zhuo, Ren-Xi
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.03.2015
• Subjects: acrylic acid; chemical elements; crosslinking; Delayed-Action Preparations - chemical synthesis; Diffusion; esters; glucosamine; glucose; Glucose - chemistry; glycosylation; Hydrogen-Ion Concentration; hydrolysis; Materials Testing; Nanocapsules - chemistry; Nanocapsules - ultrastructure; nanoparticles; Nanopores - ultrastructure; Particle Size; polyacrylic acid; polymerization; Polymers - chemistry; Porosity; porous media; silica; Silicon Dioxide - chemistry; glucose response; mesoporous silica nanoparticles; glycosylated polymer; core−shell nanoparticles; pH response; controlled drug release

In this paper, a glucose and pH-responsive release system based on polymeric network capped mesoporous silica nanoparticles (MSN) has been presented. The poly­(acrylic acid) (PAA) brush on MSN was obtained through the surface-initiated atom transfer radical polymerization (SI-ATRP) of t-butyl acryla...