Cerebrospinal fluid flow impedance is elevated in Type I Chiari malformation

• Published in: Journal of biomechanical engineering Vol. 136; no. 2; p. 021012
• Main Authors: Shaffer, Nicholas, Martin, Bryn A, Rocque, Brandon, Madura, Casey, Wieben, Oliver, Iskandar, Bermans J, Dombrowski, Stephen, Luciano, Mark, Oshinski, John N, Loth, Francis
• Format: Journal Article
• Language: English
• Published: United States 01.02.2014
• Subjects: Adolescent; Adult; Arnold-Chiari Malformation - diagnosis; Arnold-Chiari Malformation - pathology; Arnold-Chiari Malformation - physiopathology; Cerebrospinal Fluid - physiology; Cervical Vertebrae - physiopathology; Computer Simulation; Conductometry - methods; Female; Humans; Image Interpretation, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Male; Manometry - methods; Middle Aged; Models, Biological; Pressure; Reproducibility of Results; Rheology - methods; Sensitivity and Specificity; Viscosity; Young Adult

Diagnosis of Type I Chiari malformation (CMI) is difficult because the most commonly used diagnostic criterion, cerebellar tonsillar herniation (CTH) greater than 3-5 mm past the foramen magnum, has been found to have little correlation with patient symptom severity. Thus, there is a need to identif...