Human Induced Pluripotent Stem Cell-Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury

• Published in: JAMA facial plastic surgery Vol. 19; no. 3; p. 197
• Main Authors: Pepper, Jon-Paul, Wang, Tiffany V, Hennes, Valerie, Sun, Soo Yeon, Ichida, Justin K
• Format: Journal Article
• Language: English
• Published: United States 01.05.2017
• Subjects: Animals; Cells, Cultured; Disease Models, Animal; Humans; Immunohistochemistry; Induced Pluripotent Stem Cells - transplantation; Mice; Mice, Transgenic; Motor Neurons - cytology; Muscle Denervation; Muscle, Skeletal - innervation; Muscular Atrophy - therapy; Peripheral Nerve Injuries - therapy; Sciatic Nerve - injuries

Human motor neurons may be reliably derived from induced pluripotent stem cells (iPSCs). In vivo transplant studies of human iPSCs and their cellular derivatives are essential to gauging their clinical utility. To determine whether human iPSC-derived motor neurons can engraft in an immunodeficient m...