Conformational selectivity in molecular recognition: the influence of artificial receptors on the cis-trans isomerization of acylprolines

• Published in: Journal of the American Chemical Society Vol. 113; no. 14; pp. 5466 - 5467
• Main Authors: Vicent, Cristina, Hirst, Simon C, Garcia-Tellado, Fernando, Hamilton, Andrew D
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.07.1991
• Subjects: Atomic and molecular physics; Exact sciences and technology; General molecular conformation and symmetry; stereochemistry; Molecular properties and interactions with photons; Physics; Properties of molecules and molecular ions; Isomerization; NMR spectrometry; Selectivity; Experimental study; NMR spectrum; Organic compounds; Conformation; Macrocycle

The cis-trans isomerization of acylprolyl groups is a kinetically significant step in protein folding and, as such, has been the subject of intense scrutiny. This interest has increased with the recent identification of a family of enzymes that catalyze this interconversion and the important role th...