Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study

• Published in: Diabetes care Vol. 39; no. 2; pp. 264 - 270
• Main Authors: Rickels, Michael R., Ruedy, Katrina J., Foster, Nicole C., Piché, Claude A., Dulude, Hélène, Sherr, Jennifer L., Tamborlane, William V., Bethin, Kathleen E., DiMeglio, Linda A., Wadwa, R. Paul, Ahmann, Andrew J., Haller, Michael J., Nathan, Brandon M., Marcovina, Santica M., Rampakakis, Emmanouil, Meng, Linyan, Beck, Roy W.
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.02.2016
• Subjects: Administration, Intranasal; Adult; Blood Glucose - drug effects; Consciousness; Convulsions & seizures; Cross-Over Studies; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Epidemiology/Health Services Research; Female; Glucagon - administration & dosage; Glucose; Hormones - therapeutic use; Humans; Hypoglycemia; Hypoglycemia - chemically induced; Insulin - therapeutic use; Male; Medical treatment; Middle Aged; Young Adult

Treatment of severe hypoglycemia with loss of consciousness or seizure outside of the hospital setting is presently limited to intramuscular glucagon requiring reconstitution immediately prior to injection, a process prone to error or omission. A needle-free intranasal glucagon preparation was compa...