Bacteria-Inspired Nanomedicine

The natural world has provided a host of materials and inspiration for the field of nanomedicine. By taking design cues from naturally occurring systems, the nanoengineering of advanced biomimetic platforms has significantly accelerated over the past decade. In particular, the biomimicry of bacteria...

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Published inACS applied bio materials Vol. 4; no. 5; pp. 3830 - 3848
Main Authors Holay, Maya, Guo, Zhongyuan, Pihl, Jessica, Heo, Jiyoung, Park, Joon Ho, Fang, Ronnie H, Zhang, Liangfang
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 17.05.2021
Subjects
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Humans
Materials Testing
Microbial Sensitivity Tests
Nanomedicine
Particle Size
nanomedicine
drug delivery
immune modulation
biomimetic
therapeutic bacteria
Nanomedicine
Online AccessGet full text
ISSN2576-6422
2576-6422
DOI10.1021/acsabm.0c01072

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Abstract The natural world has provided a host of materials and inspiration for the field of nanomedicine. By taking design cues from naturally occurring systems, the nanoengineering of advanced biomimetic platforms has significantly accelerated over the past decade. In particular, the biomimicry of bacteria, with their motility, taxis, immunomodulation, and overall dynamic host interactions, has elicited substantial interest and opened up exciting avenues of research. More recently, advancements in genetic engineering have given way to more complex and elegant systems with tunable control characteristics. Furthermore, bacterial derivatives such as membrane ghosts, extracellular vesicles, spores, and toxins have proven advantageous for use in nanotherapeutic applications, as they preserve many of the features from the original bacteria while also offering distinct advantages. Overall, bacteria-inspired nanomedicines can be employed in a range of therapeutic settings, from payload delivery to immunotherapy, and have proven successful in combatting both cancer and infectious disease.
AbstractList The natural world has provided a host of materials and inspiration for the field of nanomedicine. By taking design cues from naturally occurring systems, the nanoengineering of advanced biomimetic platforms has significantly accelerated over the past decade. In particular, the biomimicry of bacteria, with their motility, taxis, immunomodulation, and overall dynamic host interactions, has elicited substantial interest and opened up exciting avenues of research. More recently, advancements in genetic engineering have given way to more complex and elegant systems with tunable control characteristics. Furthermore, bacterial derivatives such as membrane ghosts, extracellular vesicles, spores, and toxins have proven advantageous for use in nanotherapeutic applications, as they preserve many of the features from the original bacteria while also offering distinct advantages. Overall, bacteria-inspired nanomedicines can be employed in a range of therapeutic settings, from payload delivery to immunotherapy, and have proven successful in combatting both cancer and infectious disease.
The natural world has provided a host of materials and inspiration for the field of nanomedicine. By taking design cues from naturally occurring systems, the nanoengineering of advanced biomimetic platforms has significantly accelerated over the past decade. In particular, the biomimicry of bacteria, with their motility, taxis, immunomodulation, and overall dynamic host interactions, has elicited substantial interest and opened up exciting avenues of research. More recently, advancements in genetic engineering have given way to more complex and elegant systems with tunable control characteristics. Furthermore, bacterial derivatives such as membrane ghosts, extracellular vesicles, spores, and toxins have proven advantageous for use in nanotherapeutic applications, as they preserve many of the features from the original bacteria while also offering distinct advantages. Overall, bacteria-inspired nanomedicines can be employed in a range of therapeutic settings, from payload delivery to immunotherapy, and have proven successful in combatting both cancer and infectious disease.The natural world has provided a host of materials and inspiration for the field of nanomedicine. By taking design cues from naturally occurring systems, the nanoengineering of advanced biomimetic platforms has significantly accelerated over the past decade. In particular, the biomimicry of bacteria, with their motility, taxis, immunomodulation, and overall dynamic host interactions, has elicited substantial interest and opened up exciting avenues of research. More recently, advancements in genetic engineering have given way to more complex and elegant systems with tunable control characteristics. Furthermore, bacterial derivatives such as membrane ghosts, extracellular vesicles, spores, and toxins have proven advantageous for use in nanotherapeutic applications, as they preserve many of the features from the original bacteria while also offering distinct advantages. Overall, bacteria-inspired nanomedicines can be employed in a range of therapeutic settings, from payload delivery to immunotherapy, and have proven successful in combatting both cancer and infectious disease.
Author Guo, Zhongyuan
Fang, Ronnie H
Zhang, Liangfang
Holay, Maya
Pihl, Jessica
Heo, Jiyoung
Park, Joon Ho
AuthorAffiliation Department of NanoEngineering, Chemical Engineering Program, and Moores Cancer Center
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Issue 5
Keywords nanomedicine
drug delivery
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biomimetic
therapeutic bacteria
Nanomedicine
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Snippet The natural world has provided a host of materials and inspiration for the field of nanomedicine. By taking design cues from naturally occurring systems, the...
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SubjectTerms Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Humans
Materials Testing
Microbial Sensitivity Tests
Nanomedicine
Particle Size
Title Bacteria-Inspired Nanomedicine
URI http://dx.doi.org/10.1021/acsabm.0c01072
https://www.ncbi.nlm.nih.gov/pubmed/34368643
https://www.proquest.com/docview/2559662652
https://pubmed.ncbi.nlm.nih.gov/PMC8336673
Volume 4
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