Adverse Interactions of Luminescent Semiconductor Quantum Dots with Liposomes and Shewanella oneidensis
Cadmium-containing luminescent quantum dots (QD) are increasingly used in display, bioimaging, and energy technologies; however, significant concerns have been raised about their potentially adverse impact on human health and the environment. This study makes use of a broad toolkit of analytical met...
Saved in:
Published in | ACS applied nano materials Vol. 1; no. 9; pp. 4788 - 4800 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
28.09.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Cadmium-containing luminescent quantum dots (QD) are increasingly used in display, bioimaging, and energy technologies; however, significant concerns have been raised about their potentially adverse impact on human health and the environment. This study makes use of a broad toolkit of analytical methods to investigate and increase our understanding of the interactions of luminescent cadmium-containing (CdSe) and cadmium-free (ZnSe) QD, with and without a passivating higher bandgap energy ZnS shell, with phospholipid vesicles (liposomes), which model bacterial membranes, and with Shewanella oneidensis MR-1, an environmentally relevant bacteria. A unique feature of this study is that all QD types have the same surface chemistry, being capped with uncharged poly(ethylene glycol) ligands. This enables focusing the study on the impact of the QD core on liposomes and bacterial cells. The study reveals that QD association with liposome and bacterial cell membranes is imperative for their adverse impact on liposomes and bacterial cells. The QD' concentration-dependent association with liposomes and bacterial cells destabilizes the membranes mechanically, which leads to membrane disruption and lysis in liposomes and to bacterial cell death. The study also shows that cadmium-containing QD exhibit a higher level of membrane disruption in bacterial cells than cadmium-free QD. ZnSe QD have low membrane impact, and coating them with a ZnS shell decreases their membrane disruption activity. In contrast, CdSe QD exhibit a high level of membrane impact, and coating them with a ZnS shell does not decrease, but in fact further increases, their membrane disruption activity. This behavior might be attributed to higher affinity and association of CdSe/ZnS QD with liposomes and bacterial cells and to a contribution of dissolved zinc ions from the ZnS shell to increased membrane disruption activity. |
---|---|
AbstractList | Cadmium-containing luminescent quantum dots (QD) are increasingly used in display, bioimaging, and energy technologies; however, significant concerns have been raised about their potentially adverse impact on human health and the environment. This study makes use of a broad toolkit of analytical methods to investigate and increase our understanding of the interactions of luminescent cadmium-containing (CdSe) and cadmium-free (ZnSe) QD, with and without a passivating higher bandgap energy ZnS shell, with phospholipid vesicles (liposomes), which model bacterial membranes, and with Shewanella oneidensis MR-1, an environmentally relevant bacteria. A unique feature of this study is that all QD types have the same surface chemistry, being capped with uncharged poly(ethylene glycol) ligands. This enables focusing the study on the impact of the QD core on liposomes and bacterial cells. The study reveals that QD association with liposome and bacterial cell membranes is imperative for their adverse impact on liposomes and bacterial cells. The QD' concentration-dependent association with liposomes and bacterial cells destabilizes the membranes mechanically, which leads to membrane disruption and lysis in liposomes and to bacterial cell death. The study also shows that cadmium-containing QD exhibit a higher level of membrane disruption in bacterial cells than cadmium-free QD. ZnSe QD have low membrane impact, and coating them with a ZnS shell decreases their membrane disruption activity. In contrast, CdSe QD exhibit a high level of membrane impact, and coating them with a ZnS shell does not decrease, but in fact further increases, their membrane disruption activity. This behavior might be attributed to higher affinity and association of CdSe/ZnS QD with liposomes and bacterial cells and to a contribution of dissolved zinc ions from the ZnS shell to increased membrane disruption activity. Cadmium-containing luminescent quantum dots (QD) are increasingly used in display, bioimaging, and energy technologies; however, significant concerns have been raised about their potentially adverse impact on human health and the environment. This study makes use of a broad toolkit of analytical methods to investigate and increase our understanding of the interactions of luminescent cadmium-containing (CdSe) and cadmium-free (ZnSe) QD, with and without a passivating higher bandgap energy ZnS shell, with phospholipid vesicles (liposomes), which model bacterial membranes, and with Shewanella oneidensis MR-1, an environmentally relevant bacteria. A unique feature of this study is that all QD types have the same surface chemistry, being capped with uncharged poly(ethylene glycol) ligands. This enables focusing the study on the impact of the QD core on liposomes and bacterial cells. The study reveals that QD association with liposome and bacterial cell membranes is imperative for their adverse impact on liposomes and bacterial cells. The QD’ concentration-dependent association with liposomes and bacterial cells destabilizes the membranes mechanically, which leads to membrane disruption and lysis in liposomes and to bacterial cell death. The study also shows that cadmium-containing QD exhibit a higher level of membrane disruption in bacterial cells than cadmium-free QD. ZnSe QD have low membrane impact, and coating them with a ZnS shell decreases their membrane disruption activity. In contrast, CdSe QD exhibit a high level of membrane impact, and coating them with a ZnS shell does not decrease, but in fact further increases, their membrane disruption activity. This behavior might be attributed to higher affinity and association of CdSe/ZnS QD with liposomes and bacterial cells and to a contribution of dissolved zinc ions from the ZnS shell to increased membrane disruption activity. Cadmium-containing luminescent quantum dots (QD) are increasingly used in display, bioimaging, and energy technologies; however, significant concerns have been raised about their potentially adverse impact on human health and the environment. This study makes use of a broad toolkit of analytical methods to investigate and increase our understanding of the interactions of luminescent cadmium-containing (CdSe) and cadmium-free (ZnSe) QD, with and without a passivating higher bandgap energy ZnS shell, with phospholipid vesicles (liposomes), which model bacterial membranes, and with MR-1, an environmentally relevant bacteria. A unique feature of this study is that all QD types have the same surface chemistry, being capped with uncharged poly(ethylene glycol) ligands. This enables focusing the study on the impact of the QD core on liposomes and bacterial cells. The study reveals that QD association with liposome and bacterial cell membranes is imperative for their adverse impact on liposomes and bacterial cells. The QD' concentration-dependent association with liposomes and bacterial cells destabilizes the membranes mechanically, which leads to membrane disruption and lysis in liposomes and to bacterial cell death. The study also shows that cadmium-containing QD exhibit a higher level of membrane disruption in bacterial cells than cadmium-free QD. ZnSe QD have low membrane impact, and coating them with a ZnS shell decreases their membrane disruption activity. In contrast, CdSe QD exhibit a high level of membrane impact, and coating them with a ZnS shell does not decrease, but in fact further increases, their membrane disruption activity. This behavior might be attributed to higher affinity and association of CdSe/ZnS QD with liposomes and bacterial cells and to a contribution of dissolved zinc ions from the ZnS shell to increased membrane disruption activity. |
Author | Pramanik, Sunipa Haynes, Christy L Rosenzweig, Zeev McIntire, Eileen Hudson-Smith, Natalie V Brown, Richard P Zhi, Bo Williams, Denise N |
AuthorAffiliation | Department of Chemistry Department of Chemistry and Biochemistry |
AuthorAffiliation_xml | – name: Department of Chemistry – name: Department of Chemistry and Biochemistry – name: Department of Chemistry, University of Minnesota, Minneapolis 55455, Minnesota, United States – name: Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore 21250, Maryland, United States |
Author_xml | – sequence: 1 givenname: Denise N orcidid: 0000-0002-6314-2052 surname: Williams fullname: Williams, Denise N organization: Department of Chemistry and Biochemistry – sequence: 2 givenname: Sunipa orcidid: 0000-0001-6450-2593 surname: Pramanik fullname: Pramanik, Sunipa organization: Department of Chemistry – sequence: 3 givenname: Richard P orcidid: 0000-0001-5145-5425 surname: Brown fullname: Brown, Richard P organization: Department of Chemistry and Biochemistry – sequence: 4 givenname: Bo orcidid: 0000-0002-1918-5012 surname: Zhi fullname: Zhi, Bo organization: Department of Chemistry – sequence: 5 givenname: Eileen orcidid: 0000-0001-8034-7087 surname: McIntire fullname: McIntire, Eileen organization: Department of Chemistry – sequence: 6 givenname: Natalie V orcidid: 0000-0002-2642-0711 surname: Hudson-Smith fullname: Hudson-Smith, Natalie V organization: Department of Chemistry – sequence: 7 givenname: Christy L orcidid: 0000-0002-5420-5867 surname: Haynes fullname: Haynes, Christy L organization: Department of Chemistry – sequence: 8 givenname: Zeev orcidid: 0000-0001-6098-3932 surname: Rosenzweig fullname: Rosenzweig, Zeev email: zrosenzw@umbc.edu organization: Department of Chemistry and Biochemistry |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30931431$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kd1LXDEQxUNR6kd97aPksQi7TnK_9r4URFsVFkqxfQ5zk4kb2ZusSa7S_76RXcU-9CkD-c2ZM3OO2J4Pnhj7LGAuQIpz1An9OF8MIADgAzuUTVfPoO9g7119wE5SeiiA6EVbAXxkBxX0lagrccjuL8wTxUT81meKqLMLPvFg-XIanaekyWd-R6PTwZtJ5xD5zwl9nkZ-FXLizy6v-NJtQgojJY7e8LsVPaOn9Rp5sesM-eTSJ7ZvcZ3oZPces9_fv_26vJktf1zfXl4sZ1jLJs-0bHCQgx2ERdlawNriAGjBLHDRCoOm64y2nYGm17CQBgY0FQFKY4YGdXXMvm51N9MwknmxH3GtNtGNGP-ogE79--PdSt2HJ9XWVVNBVwS-7ARieJwoZTW6coWyjacwJSUliE70Xd8WdL5FdQwpRbJvYwSol4DUNiC1C6g0nL4394a_xlGAsy1QGtVDmKIvt_qf2l8Sy6GD |
CitedBy_id | crossref_primary_10_1007_s12551_020_00653_0 crossref_primary_10_1021_acsami_2c02551 crossref_primary_10_1016_j_radphyschem_2022_110731 crossref_primary_10_1016_j_jphotochem_2024_115757 crossref_primary_10_1073_pnas_2004736117 crossref_primary_10_2174_2405461507666220304204152 crossref_primary_10_3390_coatings13010212 crossref_primary_10_1021_acsanm_9b00525 crossref_primary_10_1007_s11033_020_05522_3 crossref_primary_10_1021_acs_jpcc_0c01195 crossref_primary_10_1021_jacs_2c13403 crossref_primary_10_1016_j_cclet_2023_108689 crossref_primary_10_1039_C8CC06473C crossref_primary_10_1016_j_ecoenv_2021_112459 crossref_primary_10_1016_j_impact_2021_100318 crossref_primary_10_1021_acsanm_0c01386 crossref_primary_10_1021_acs_jpca_3c07462 crossref_primary_10_1039_D3EN00382E crossref_primary_10_1063_1_5128608 crossref_primary_10_1063_5_0017229 crossref_primary_10_1021_acs_accounts_9b00053 |
Cites_doi | 10.1021/acs.jpclett.6b00077 10.1021/acs.langmuir.7b01924 10.1021/nl048245n 10.1021/nl0347334 10.1021/nn700319z 10.1021/acs.chemrev.6b00290 10.1021/cm9027995 10.1002/cphc.201500837 10.1021/acs.jpclett.5b02153 10.1021/nl5048779 10.1063/1.4901428 10.1021/ac303636s 10.1038/nbt749 10.1021/jp906827m 10.1021/acs.langmuir.7b00173 10.1021/la704075r 10.1038/nprot.2008.243 10.1016/j.jallcom.2015.02.102 10.1289/ehp.8284 10.1002/smll.200800841 10.1021/nn8008933 10.1021/acs.langmuir.6b04400 10.1016/j.brainresbull.2013.10.012 10.1021/jf0348368 10.1016/j.spjpm.2015.11.003 10.1039/C5SC00792E 10.3390/ma11020243 10.1039/b810488c 10.1021/ja042939g 10.1021/acs.langmuir.7b04285 10.1063/1.4817086 10.1021/es8023385 10.1021/nn1025934 10.1007/s00253-017-8140-9 10.1016/j.orgel.2013.11.003 10.1155/2015/298614 10.1021/es802806n 10.1002/jbio.201300067 10.1002/smll.201402698 10.1039/C4TX00123K 10.1039/b413175d 10.1093/toxsci/kfv002 10.1021/ja076363h 10.1021/acs.chemmater.5b04505 10.1088/0022-3727/38/13/001 10.1002/jemt.22637 10.1039/C3NJ00998J 10.1016/j.jfda.2014.01.005 10.1038/nmat1390 10.1007/4243_2012_43 10.1002/jbio.201400051 |
ContentType | Journal Article |
DBID | NPM AAYXX CITATION 7X8 5PM |
DOI | 10.1021/acsanm.8b01000 |
DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Physics |
EISSN | 2574-0970 |
EndPage | 4800 |
ExternalDocumentID | 10_1021_acsanm_8b01000 30931431 c014173050 |
Genre | Journal Article |
GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: R25 GM055036 – fundername: NIGMS NIH HHS grantid: T32 GM066706 |
GroupedDBID | ABUCX ACGFS ACS AFEFF ALMA_UNASSIGNED_HOLDINGS EBS EJD VF5 VG9 W1F ABQRX BAANH CUPRZ GGK NPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-a425t-c25ab2bfb1fa26f0a4fab0af0d8a861dad77dcf7d059c082d0bad3e0a2ddb5ac3 |
IEDL.DBID | ACS |
ISSN | 2574-0970 |
IngestDate | Tue Sep 17 21:22:25 EDT 2024 Sat Aug 17 00:35:51 EDT 2024 Fri Aug 23 02:20:41 EDT 2024 Sat Sep 28 08:30:45 EDT 2024 Thu Aug 27 13:42:28 EDT 2020 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 9 |
Keywords | quantum dots Shewanella oneidensis MR-1 membrane disruption membrane association liposomes |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-a425t-c25ab2bfb1fa26f0a4fab0af0d8a861dad77dcf7d059c082d0bad3e0a2ddb5ac3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author Contributions The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. |
ORCID | 0000-0001-6450-2593 0000-0001-6098-3932 0000-0001-5145-5425 0000-0002-6314-2052 0000-0002-5420-5867 0000-0001-8034-7087 0000-0002-1918-5012 0000-0002-2642-0711 |
OpenAccessLink | https://europepmc.org/articles/pmc6435307?pdf=render |
PMID | 30931431 |
PQID | 2201719796 |
PQPubID | 23479 |
PageCount | 13 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6435307 proquest_miscellaneous_2201719796 crossref_primary_10_1021_acsanm_8b01000 pubmed_primary_30931431 acs_journals_10_1021_acsanm_8b01000 |
ProviderPackageCode | ACS VG9 ABUCX AFEFF VF5 W1F |
PublicationCentury | 2000 |
PublicationDate | 2018-09-28 |
PublicationDateYYYYMMDD | 2018-09-28 |
PublicationDate_xml | – month: 09 year: 2018 text: 2018-09-28 day: 28 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | ACS applied nano materials |
PublicationTitleAlternate | ACS Appl. Nano Mater |
PublicationYear | 2018 |
Publisher | American Chemical Society |
Publisher_xml | – name: American Chemical Society |
References | ref9/cit9 ref45/cit45 ref3/cit3 ref27/cit27 ref16/cit16 Haldar S. (ref42/cit42) 2012; 13 ref52/cit52 ref23/cit23 ref8/cit8 ref31/cit31 ref2/cit2 ref34/cit34 ref37/cit37 ref20/cit20 ref48/cit48 ref17/cit17 ref10/cit10 ref35/cit35 ref19/cit19 ref21/cit21 ref46/cit46 ref49/cit49 ref13/cit13 ref24/cit24 ref38/cit38 ref50/cit50 ref6/cit6 ref36/cit36 ref18/cit18 ref11/cit11 ref25/cit25 ref29/cit29 ref32/cit32 ref39/cit39 ref14/cit14 ref5/cit5 ref51/cit51 ref43/cit43 ref28/cit28 ref40/cit40 ref26/cit26 ref12/cit12 ref15/cit15 ref41/cit41 ref22/cit22 ref33/cit33 ref4/cit4 ref30/cit30 ref47/cit47 ref1/cit1 ref44/cit44 ref7/cit7 |
References_xml | – ident: ref1/cit1 doi: 10.1021/acs.jpclett.6b00077 – ident: ref37/cit37 doi: 10.1021/acs.langmuir.7b01924 – ident: ref52/cit52 doi: 10.1021/nl048245n – ident: ref21/cit21 doi: 10.1021/nl0347334 – ident: ref17/cit17 doi: 10.1021/nn700319z – ident: ref3/cit3 doi: 10.1021/acs.chemrev.6b00290 – ident: ref6/cit6 doi: 10.1021/cm9027995 – ident: ref18/cit18 doi: 10.1002/cphc.201500837 – ident: ref5/cit5 doi: 10.1021/acs.jpclett.5b02153 – ident: ref10/cit10 doi: 10.1021/nl5048779 – ident: ref51/cit51 doi: 10.1063/1.4901428 – ident: ref19/cit19 doi: 10.1021/ac303636s – ident: ref31/cit31 doi: 10.1038/nbt749 – ident: ref35/cit35 doi: 10.1021/jp906827m – ident: ref22/cit22 doi: 10.1021/acs.langmuir.7b00173 – ident: ref23/cit23 doi: 10.1021/la704075r – ident: ref33/cit33 doi: 10.1038/nprot.2008.243 – ident: ref8/cit8 doi: 10.1016/j.jallcom.2015.02.102 – ident: ref26/cit26 doi: 10.1289/ehp.8284 – ident: ref9/cit9 doi: 10.1002/smll.200800841 – ident: ref27/cit27 doi: 10.1021/nn8008933 – ident: ref44/cit44 doi: 10.1021/acs.langmuir.6b04400 – ident: ref46/cit46 doi: 10.1016/j.brainresbull.2013.10.012 – ident: ref45/cit45 doi: 10.1021/jf0348368 – ident: ref13/cit13 doi: 10.1016/j.spjpm.2015.11.003 – ident: ref43/cit43 doi: 10.1039/C5SC00792E – ident: ref49/cit49 doi: 10.3390/ma11020243 – ident: ref34/cit34 doi: 10.1039/b810488c – ident: ref36/cit36 doi: 10.1021/ja042939g – ident: ref40/cit40 doi: 10.1021/acs.langmuir.7b04285 – ident: ref7/cit7 doi: 10.1063/1.4817086 – ident: ref30/cit30 doi: 10.1021/es8023385 – ident: ref39/cit39 doi: 10.1021/nn1025934 – ident: ref28/cit28 doi: 10.1007/s00253-017-8140-9 – ident: ref14/cit14 doi: 10.1016/j.orgel.2013.11.003 – ident: ref11/cit11 doi: 10.1155/2015/298614 – ident: ref20/cit20 doi: 10.1021/es802806n – ident: ref47/cit47 doi: 10.1002/jbio.201300067 – ident: ref2/cit2 doi: 10.1002/smll.201402698 – ident: ref16/cit16 doi: 10.1039/C4TX00123K – ident: ref24/cit24 doi: 10.1039/b413175d – ident: ref25/cit25 doi: 10.1093/toxsci/kfv002 – ident: ref15/cit15 doi: 10.1021/ja076363h – ident: ref32/cit32 doi: 10.1021/acs.chemmater.5b04505 – ident: ref4/cit4 doi: 10.1088/0022-3727/38/13/001 – ident: ref50/cit50 doi: 10.1002/jemt.22637 – ident: ref38/cit38 doi: 10.1039/C3NJ00998J – ident: ref41/cit41 – ident: ref12/cit12 doi: 10.1016/j.jfda.2014.01.005 – ident: ref29/cit29 doi: 10.1038/nmat1390 – volume: 13 volume-title: Fluorescent Methods to Study Biological Membranes year: 2012 ident: ref42/cit42 doi: 10.1007/4243_2012_43 contributor: fullname: Haldar S. – ident: ref48/cit48 doi: 10.1002/jbio.201400051 |
SSID | ssj0001916300 |
Score | 2.242079 |
Snippet | Cadmium-containing luminescent quantum dots (QD) are increasingly used in display, bioimaging, and energy technologies; however, significant concerns have been... |
SourceID | pubmedcentral proquest crossref pubmed acs |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 4788 |
Title | Adverse Interactions of Luminescent Semiconductor Quantum Dots with Liposomes and Shewanella oneidensis |
URI | http://dx.doi.org/10.1021/acsanm.8b01000 https://www.ncbi.nlm.nih.gov/pubmed/30931431 https://search.proquest.com/docview/2201719796 https://pubmed.ncbi.nlm.nih.gov/PMC6435307 |
Volume | 1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fa9swEBZb99KXdWPrmrUbGh3syZms-Ofj6FbKyAolK-TN3ElWG0bsUtkU-tf3zk6aJmFszxb6dSfr4-67T0J8zmNrTY5RkKc5BFGZlwEmqQ3QKQXxyMYYcXHyr_Pk7DL6OY2nq3jHZgZfh1_BeKjmwwwVh6Kfixea6YMMgk4mq2gKoZxRV29CLhgFKk_VUqFxqwu-h4xfv4e2wOUmR_LJpXO61ysg-U6rkLkmf4Ztg0Nzv63k-M_1vBIvF8hTfutd5bV4VlZvxFX3ILMvZRcZ7IscvKydHLdzJsTzvOSECfR1xcqw9a28aMkY7Vx-rxsvOYwrx7Ob2tfz0kuorJxcl3fA5BmQdcUqWpWf-bfi8vTH75OzYPH2QgB0ipvA6BhQo8PQgU6cgsgBKnDKZpAloQWbpta41BI8MwQjrEKwo1KBthZjMKN9sVPRKAdC5oTAyGKZCTGLQutQ2SRxDpGwIAuEDcQx7UmxODu-6NLiOiz6jSoWGzUQX5b2Km56IY6_tvy0NGdBZ4UTILTquvWF1qwORF6ZDMS73ryPfXFGmLBjOBDpmuEfG7AO9_qXanbd6XETqIvpV_n-v9ZxKHZpFh3lRGdHYqe5bcsPhGsa_Ni59AP4Gvel |
link.rule.ids | 230,315,786,790,891,2782,27109,27957,27958,57093,57143 |
linkProvider | American Chemical Society |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT9wwEB4BPdBLaVVoF_owKhKnLE42z2NFi7ZlQUULErdoJo7LqtoE4URI_HrGzu7SBVUq18Syx55x_GUenwH2skipIqPQy5IMvbDMSo_iRHmkpcRooCIKbXHyyWk8vAh_XkaXK3Awr4VhIQz3ZFwQ_4FdwD_gZ1hN-ylJ65FehRdRwj_jFgsdjh-cKgx2Bq7shC0x9GSWyDlR45Mu7HFUmOXj6AnGfJwq-dfZc7QBvxZSu5STP_22oX5x94jQ8RnTeg2vZjhUfO0M5w2slNVb-O2uZzalcH7CruTBiFqLUTu16fFWPDG26fR1ZXli6xtx1rJq2qn4VjdGWKeuGE2ua1NPSyOwUmJ8Vd6iTaVBUVeWU6syE7MJF0ffzw-H3uwmBg95TzdeEURIAWnyNQaxlhhqJIlaqhTT2FeokkQVOlEM1goGFUoSqkEpMVCKIiwGW7BW8SjvQWSMx3yZpYVPaegrTVLFsdZEjAwtXVgPvvCa5LOdZHIXJA_8vFuofLZQPdifqy2_7mg5_tlyd67VnHeODYfwrOvW5EFguYLYRuMevOu0vOjLxocZSfo9SJb0v2hgWbmX31STK8fOzRAv4g_n9n_N4zOsD89PRvnox-nxDrxkiVwySpB-gLXmpi0_MuJp6JOz8nvR-gAf |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9RAEF-0gviiFT96atuVCj7l3OTy-VjaHlWvRbkW-hZmM9n2KJcc3QTBv96ZTe7qtQj1NVk2szsz2R_z8VshPmURYpHp0MuSDLywzEpPxwl62igF0QgjHXJz8slpfHwefruILvo-bu6FISEszWRdEp-9eoGmZxjwv9BzqObDVCuOSj8WTyK-vZvx0MH0NrBCgGfkWk_IGkNPZYlakjXem4KPpMKuH0n3cObdcsm_zp_xC3G2ktyVnVwP20YPi993SB3_c2mb4nmPR-V-Z0AvxaOyeiUu3TXNtpQuXti1PlhZGzlp51wmzyLKKZfV1xXzxdY38mdLKmrn8rBurOTgrpzMFrWt56WVUKGcXpW_gEtqQNYVc2tVdmZfi_Px0dnBsdffyOAB-XbjFUEEOtBG-waC2CgIDWgFRmEKaewjYJJgYRIk0FYQuEClAUelggBRR1CM3oiNir6yJWRGuMxXWVr4Og19NFphHBujNSFEpg0biD3ak7z3KJu7ZHng591G5f1GDcTnperyRUfP8c-RH5eazcmDOC1Cq65bmwcBcwaRrcYD8bbT9GouzhOTifkDkazZwGoAs3Ovv6lmV46lm6BeRD_Qdw9ax654-uNwnE--nn5_L56RQK4mJUg_iI3mpi23Cfg0escZ-h_c5gKZ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Adverse+Interactions+of+Luminescent+Semiconductor+Quantum+Dots+with+Liposomes+and+Shewanella+oneidensis&rft.jtitle=ACS+applied+nano+materials&rft.au=Williams%2C+Denise+N.&rft.au=Pramanik%2C+Sunipa&rft.au=Brown%2C+Richard+P.&rft.au=Zhi%2C+Bo&rft.date=2018-09-28&rft.issn=2574-0970&rft.eissn=2574-0970&rft.volume=1&rft.issue=9&rft.spage=4788&rft.epage=4800&rft_id=info:doi/10.1021%2Facsanm.8b01000&rft.externalDBID=n%2Fa&rft.externalDocID=10_1021_acsanm_8b01000 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2574-0970&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2574-0970&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2574-0970&client=summon |