Fabrication and Characterization of Drug-Loaded Conductive Poly(glycerol sebacate)/Nanoparticle-Based Composite Patch for Myocardial Infarction Applications

• Published in: ACS applied materials & interfaces Vol. 12; no. 6; pp. 6899 - 6909
• Main Authors: Zanjanizadeh Ezazi, Nazanin, Ajdary, Rubina, Correia, Alexandra, Mäkilä, Ermei, Salonen, Jarno, Kemell, Marianna, Hirvonen, Jouni, Rojas, Orlando J, Ruskoaho, Heikki J, Santos, Hélder A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.02.2020
• Subjects: Animals; Decanoates - chemistry; Drug Delivery Systems - instrumentation; Drug Delivery Systems - methods; Electric Conductivity; Glycerol - analogs & derivatives; Glycerol - chemistry; Humans; Materials Testing; Mice; Myocardial Infarction - drug therapy; Myocytes, Cardiac - cytology; Myocytes, Cardiac - drug effects; Nanoparticles - chemistry; Polymers - chemistry; Pyrroles - chemistry; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology; polypyrrole; heart tissue engineering; drug delivery; regeneration; conductive polymers

Heart tissue engineering is critical in the treatment of myocardial infarction, which may benefit from drug-releasing smart materials. In this study, we load a small molecule (3i-1000) in new biodegradable and conductive patches for application in infarcted myocardium. The composite patches consist...