Planar Catechin Analogues with Alkyl Side Chains:  A Potent Antioxidant and an α-Glucosidase Inhibitor

• Published in: Journal of the American Chemical Society Vol. 128; no. 20; pp. 6524 - 6525
• Main Authors: Hakamata, Wataru, Nakanishi, Ikuo, Masuda, Yu, Shimizu, Takehiko, Higuchi, Hajime, Nakamura, Yuriko, Saito, Shinichi, Urano, Shiro, Oku, Tadatake, Ozawa, Toshihiko, Ikota, Nobuo, Miyata, Naoki, Okuda, Haruhiro, Fukuhara, Kiyoshi
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 24.05.2006; Amer Chemical Soc
• Subjects: alpha-Glucosidases; Analytical, structural and metabolic biochemistry; Antioxidants - pharmacology; Biological and medical sciences; Catechin - analogs & derivatives; Catechin - chemical synthesis; Catechin - pharmacology; Chemistry; Chemistry, Multidisciplinary; Enzymes and enzyme inhibitors; Fundamental and applied biological sciences. Psychology; Geobacillus stearothermophilus - enzymology; Glycoside Hydrolase Inhibitors; Hydrolases; Physical Sciences; Saccharomyces cerevisiae - enzymology; Science & Technology; APOPTOSIS; CANCER; Structure effect; Enzyme; Chain length; Enzyme inhibitor; Antioxidant; Flavonoid; Radical scavenger; Biological activity; Polyphenol; α-Glucosidase; Glycosidases; Hydrolases; O-Glycosidases; Lipophilicity
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja057763c

Planar catechin analogues having various alkyl side chain lengths were synthesized, and their remarkable antioxidative abilities and alpha-glucosidase inhibitory activities are shown.Planar catechin analogues having various alkyl side chain lengths were synthesized, and their remarkable antioxidative abilities and alpha-glucosidase inhibitory activities are shown.