N-[18F]Fluoroethylpiperidin-4ylmethyl Acetate, a Novel Lipophilic Acetylcholine Analogue for PET Measurement of Brain Acetylcholinesterase Activity - Kikuchi, Tatsuya; Zhang, Ming-Rong; Ikota, Nobuo; Fukushi, Kiyoshi; Okamura, Toshimitsu; Suzuki, Kazutoshi; Arano, Yasushi; Irie, Toshiaki (Journal of medicinal chemistry, 2005)
Keywords: Acetates - chemical synthesis; Acetates - chemistry; Acetates - pharmacokinetics; Acetylcholine - analogs & derivatives; Acetylcholine - chemical synthesis; Acetylcholine - chemistry; Acetylcholine - pharmacokinetics; Acetylcholinesterase - chemistry; Acetylcholinesterase - metabolism; Animals; Biological and medical sciences; Blood-Brain Barrier - metabolism; Brain - enzymology; Brain - metabolism; Chemistry, Medicinal; Cholinesterase Inhibitors - pharmacology; Contrast media. Radiopharmaceuticals; Fluorine Radioisotopes; Humans; Hydrolysis; In Vitro Techniques; Life Sciences & Biomedicine; Male; Medical sciences; Membranes, Artificial; Permeability; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Piperidines - chemical synthesis; Piperidines - chemistry; Piperidines - pharmacokinetics; Positron-Emission Tomography; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - pharmacokinetics; Rats; Rats, Wistar; Science & Technology; Structure-Activity Relationship; Tissue Distribution; POSITRON-EMISSION-TOMOGRAPHY; TRACER; RADIOTRACERS; ESTERS; Fluorine Isotopes; Fluorine 18; Radiolabelling; Rat; Enzyme; Rodentia; Central nervous system; Esterases; Acetylcholinesterase; Blood brain barrier; Biological activity; Carboxylic ester hydrolases; Lipophilic compound; Vertebrata; Mammalia; Absorption; Animal; Distribution; Hydrolases; Pharmacokinetics; Positron emission tomography