Prevalence in the United States of aac(6′)-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme
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| Published in | Antimicrobial Agents and Chemotherapy Vol. 50; no. 11; pp. 3953 - 3955 |
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American Society for Microbiology
01.11.2006
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Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes.Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes. Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes. Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of ≥0.25 μg/ml and reduced susceptibility to ceftazidime, aac(6′)-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6′)-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes. Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of ≥0.25 μg/ml and reduced susceptibility to ceftazidime, aac(6 ′ )-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6 ′ )-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli , equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes. Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of greater than or equal to 0.25 mu g/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes. |
| Author | George A. Jacoby Daniel Sahm David C. Hooper Chi Hye Park Ari Robicsek |
| AuthorAffiliation | Massachusetts General Hospital, Boston, Massachusetts, 1 Evanston Northwestern Healthcare, Evanston, Illinois, 2 Lahey Clinic, Burlington, Massachusetts, 3 Focus BioInova, Herndon, Virginia 4 |
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| Keywords | Fluoroquinolone derivatives Prevalence Enzyme Antibacterial agent Ciprofloxacin Epidemiology Quinolone derivatives |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author. Mailing address: Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114-2696. Phone: (617) 643-3856. Fax: (617) 726-7416. E-mail: dhooper@partners.org. |
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| References | 10984324 - Clin Infect Dis. 2000 Aug;31 Suppl 2:S24-8 15047532 - Antimicrob Agents Chemother. 2004 Apr;48(4):1295-9 16569827 - Antimicrob Agents Chemother. 2006 Apr;50(4):1178-82 12821475 - Antimicrob Agents Chemother. 2003 Jul;47(7):2242-8 15673773 - Antimicrob Agents Chemother. 2005 Feb;49(2):801-3 16369542 - Nat Med. 2006 Jan;12(1):83-8 16020539 - J Antimicrob Chemother. 2005 Sep;56(3):463-9 11504468 - Drug Resist Updat. 1999 Feb;2(1):38-55 9527761 - Antimicrob Agents Chemother. 1998 Feb;42(2):209-15 9519952 - Lancet. 1998 Mar 14;351(9105):797-9 16870791 - Antimicrob Agents Chemother. 2006 Aug;50(8):2872-4 11943863 - Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5638-42 |
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Reddit... Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was... Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of ≥0.25 μg/ml and reduced susceptibility to ceftazidime, aac(6′)-Ib was present... Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of greater than or equal to 0.25 mu g/ml and reduced susceptibility to... Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of ≥0.25 μg/ml and reduced susceptibility to ceftazidime, aac(6 ′ )-Ib was present... |
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| SubjectTerms | Acetyltransferases Acetyltransferases - genetics Anti-Bacterial Agents Anti-Bacterial Agents - metabolism Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ciprofloxacin Ciprofloxacin - metabolism Cross-Sectional Studies Drug Resistance, Bacterial - genetics Enterobacteriaceae Enterobacteriaceae - enzymology Enterobacteriaceae - genetics Enterobacteriaceae Infections - epidemiology Enterobacteriaceae Infections - microbiology Escherichia coli Escherichia coli - drug effects Klebsiella pneumoniae - drug effects Mechanisms of Resistance Medical sciences Microbial Sensitivity Tests Odds Ratio Pharmacology. Drug treatments United States - epidemiology |
| Title | Prevalence in the United States of aac(6′)-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme |
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