Synthesis of Atropisomers by Transition-Metal-Catalyzed Asymmetric C–H Functionalization Reactions

• Published in: Journal of the American Chemical Society Vol. 143; no. 35; pp. 14025 - 14040
• Main Authors: Liu, Chen-Xu, Zhang, Wen-Wen, Yin, Si-Yong, Gu, Qing, You, Shu-Li
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.09.2021
• Subjects: carbon-hydrogen bond activation; catalytic activity; enantioselectivity; ligands; stereoselective synthesis

Transition-metal-catalyzed enantio­selective C–H functionalization has become a powerful strategy for the formation of C–C or C–X bonds, enabling the highly asymmetric synthesis of a wide range of enantio­enriched compounds. Atrop­isomers are widely found in natural products and pharmaceutically rel...