Substrate Preference and Interplay of Fucosyltransferase 8 and N‑Acetylglucosaminyltransferases

• Published in: Journal of the American Chemical Society Vol. 139; no. 28; pp. 9431 - 9434
• Main Authors: Tseng, Tzu-Hao, Lin, Tzu-Wen, Chen, Chien-Yu, Chen, Chein-Hung, Lin, Jung-Lee, Hsu, Tsui-Ling, Wong, Chi-Huey
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.07.2017
• Subjects: disease course; glycopeptides; glycoproteins; glycosylation; glycosyltransferases; humans; N-acetylglucosamine; neoplasms; polysaccharides; postnatal development; substrate specificity

The core fucosylation of N-glycans on glyco­proteins is catalyzed by fucosyl­transferase 8 (FUT8) in mammalian cells and is involved in various biological functions, such as protein function, cancer progression, and post­natal development. The substrate specificity of FUT8 toward bi-antennary N-glyc...