Controlled Release of an Anti-inflammatory Drug Using an Ultrasensitive ROS-Responsive Gas-Generating Carrier for Localized Inflammation Inhibition

• Published in: Journal of the American Chemical Society Vol. 137; no. 39; pp. 12462 - 12465
• Main Authors: Chung, Ming-Fan, Chia, Wei-Tso, Wan, Wei-Lin, Lin, Yu-Jung, Sung, Hsing-Wen
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.10.2015
• Subjects: anti-inflammatory agents; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; bubbles; carbon dioxide; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - pharmacology; Drug Carriers - chemistry; encapsulation; ethanol; ferrous chloride; Gases - chemistry; hydrogen peroxide; inflammation; Inflammation - drug therapy; iron; Limit of Detection; Microspheres; osteoarthritis; Reactive Oxygen Species; sodium bicarbonate; therapeutics

Inflammation is associated with many diseases, in which activated inflammatory cells produce various reactive oxygen species (ROS), including H2O2. This work proposes an ultrasensitive ROS-responsive hollow microsphere (HM) carrier that contains an anti-inflammatory drug, an acid precursor consistin...