Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions - Chen, Kai; Zhang, Shuo-Qing; Brandenberg, Oliver F; Hong, Xin; Arnold, Frances H (Journal of the American Chemical Society, 2018)
Keywords: carbenes; catalytic activity; chemical bonding; Chemistry; Chemistry, Multidisciplinary; cytochrome P-450; enzymes; heme; lactones; ligands; olefin; Physical Sciences; Science & Technology; steers; stereoselectivity; IRON PORPHYRIN CARBENES; SUBSTITUENT; INSERTION; ENANTIOSELECTIVE S-H; CONSTRUCTION; CYCLOPROPANATION; CATALYZED INTERMOLECULAR REACTIONS; LACTONE BUILDING-BLOCKS; BIOCATALYTIC PREPARATION