Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors
Cell adhesive and other functional peptides (such as RGD, KRSR, YIGSR, VAPG, and BMP-2 peptides) are extensively studied and utilized in tissue engineering scaffolds and biomedical devices to modulate cell functions. Though PEG is frequently used as the antifouling layer, it is unclear how it affect...
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| Published in | Journal of the American Chemical Society Vol. 141; no. 42; pp. 16772 - 16780 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
23.10.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Cell adhesive and other functional peptides (such as RGD, KRSR, YIGSR, VAPG, and BMP-2 peptides) are extensively studied and utilized in tissue engineering scaffolds and biomedical devices to modulate cell functions. Though PEG is frequently used as the antifouling layer, it is unclear how it affects the performance of functional peptides. By analyzing the impact of PEG at short (OEG4), medium (OEG8), and long chain length (PEG2K), we reveal that PEG chain length is critical and a medium-length PEG enables functional peptides to display their optimal and genuine functions in cell adhesion, migration, and differentiation by providing excellent antifouling to minimize background noise of unwanted cell adhesion and high enough surface density of functional peptides. Our result provides new avenues for maximizing the genuine functions of peptides. This study also provides a solution to prevent the heterogeneous and even divergent results caused by inappropriate choice of antifouling PEG and provides a general guidance in identifying new functional peptides. |
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| AbstractList | Cell adhesive and other functional peptides (such as RGD, KRSR, YIGSR, VAPG, and BMP-2 peptides) are extensively studied and utilized in tissue engineering scaffolds and biomedical devices to modulate cell functions. Though PEG is frequently used as the antifouling layer, it is unclear how it affects the performance of functional peptides. By analyzing the impact of PEG at short (OEG4), medium (OEG8), and long chain length (PEG2K), we reveal that PEG chain length is critical and a medium-length PEG enables functional peptides to display their optimal and genuine functions in cell adhesion, migration, and differentiation by providing excellent antifouling to minimize background noise of unwanted cell adhesion and high enough surface density of functional peptides. Our result provides new avenues for maximizing the genuine functions of peptides. This study also provides a solution to prevent the heterogeneous and even divergent results caused by inappropriate choice of antifouling PEG and provides a general guidance in identifying new functional peptides. Cell adhesive and other functional peptides (such as RGD, KRSR, YIGSR, VAPG, and BMP-2 peptides) are extensively studied and utilized in tissue engineering scaffolds and biomedical devices to modulate cell functions. Though PEG is frequently used as the antifouling layer, it is unclear how it affects the performance of functional peptides. By analyzing the impact of PEG at short (OEG4), medium (OEG8), and long chain length (PEG2K), we reveal that PEG chain length is critical and a medium-length PEG enables functional peptides to display their optimal and genuine functions in cell adhesion, migration, and differentiation by providing excellent antifouling to minimize background noise of unwanted cell adhesion and high enough surface density of functional peptides. Our result provides new avenues for maximizing the genuine functions of peptides. This study also provides a solution to prevent the heterogeneous and even divergent results caused by inappropriate choice of antifouling PEG and provides a general guidance in identifying new functional peptides.Cell adhesive and other functional peptides (such as RGD, KRSR, YIGSR, VAPG, and BMP-2 peptides) are extensively studied and utilized in tissue engineering scaffolds and biomedical devices to modulate cell functions. Though PEG is frequently used as the antifouling layer, it is unclear how it affects the performance of functional peptides. By analyzing the impact of PEG at short (OEG4), medium (OEG8), and long chain length (PEG2K), we reveal that PEG chain length is critical and a medium-length PEG enables functional peptides to display their optimal and genuine functions in cell adhesion, migration, and differentiation by providing excellent antifouling to minimize background noise of unwanted cell adhesion and high enough surface density of functional peptides. Our result provides new avenues for maximizing the genuine functions of peptides. This study also provides a solution to prevent the heterogeneous and even divergent results caused by inappropriate choice of antifouling PEG and provides a general guidance in identifying new functional peptides. |
| Author | Yu, Shan Zou, Jingcheng Mao, Zhengwei Zhang, Donghui Zhang, Haodong Liu, Runhui Yuan, Yuan Chen, Qi Gao, Changyou Zhang, Wenjing |
| AuthorAffiliation | State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering |
| AuthorAffiliation_xml | – name: State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering – name: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering |
| Author_xml | – sequence: 1 givenname: Qi orcidid: 0000-0002-5982-9249 surname: Chen fullname: Chen, Qi organization: State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering – sequence: 2 givenname: Shan surname: Yu fullname: Yu, Shan organization: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering – sequence: 3 givenname: Donghui orcidid: 0000-0002-8934-8550 surname: Zhang fullname: Zhang, Donghui organization: State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering – sequence: 4 givenname: Wenjing orcidid: 0000-0002-6076-8017 surname: Zhang fullname: Zhang, Wenjing organization: State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering – sequence: 5 givenname: Haodong orcidid: 0000-0002-1186-8732 surname: Zhang fullname: Zhang, Haodong organization: State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering – sequence: 6 givenname: Jingcheng orcidid: 0000-0002-4839-9650 surname: Zou fullname: Zou, Jingcheng organization: State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering – sequence: 7 givenname: Zhengwei orcidid: 0000-0001-7990-2856 surname: Mao fullname: Mao, Zhengwei organization: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering – sequence: 8 givenname: Yuan orcidid: 0000-0001-7877-3175 surname: Yuan fullname: Yuan, Yuan organization: State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering – sequence: 9 givenname: Changyou orcidid: 0000-0001-5084-7208 surname: Gao fullname: Gao, Changyou organization: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering – sequence: 10 givenname: Runhui orcidid: 0000-0002-7699-086X surname: Liu fullname: Liu, Runhui email: rliu@ecust.edu.cn organization: State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31573191$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/adma.201501351 10.1016/j.colsurfb.2011.01.028 10.1002/jbm.a.10110 10.1371/journal.pone.0050880 10.1038/nmat3937 10.1016/j.biomaterials.2015.12.030 10.1016/j.actbio.2010.12.021 10.1038/s41578-018-0023-x 10.1016/j.biomaterials.2005.01.045 10.1038/s41467-018-05837-7 10.1021/acsami.6b09375 10.1021/acs.biomac.6b00088 10.1038/ncomms15982 10.1021/acs.chemrev.7b00094 10.1021/acs.nanolett.5b01619 10.1002/adma.201504394 10.1021/acs.biomac.5b00219 10.1093/oxfordjournals.jbchem.a124315 10.1002/anie.201400546 10.1002/smll.201402038 10.1016/j.actbio.2009.03.001 10.1016/j.tibtech.2018.01.008 10.1021/bm201847n 10.1016/S0142-9612(02)00129-1 10.1002/adhm.201700944 10.1016/S1570-9639(03)00235-8 10.1002/adma.200901407 10.1021/acs.biomac.8b00264 10.1016/j.mattod.2017.07.002 10.1021/acsami.8b01117 10.1038/309030a0 10.1021/ja9050636 10.1002/anie.201808987 10.1016/S0021-9258(18)53062-3 10.1021/acsnano.6b01765 10.1021/am405124z 10.1016/j.pmatsci.2012.09.002 |
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| Snippet | Cell adhesive and other functional peptides (such as RGD, KRSR, YIGSR, VAPG, and BMP-2 peptides) are extensively studied and utilized in tissue engineering... |
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| SubjectTerms | cell adhesion medical equipment peptides tissue engineering |
| Title | Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors |
| URI | http://dx.doi.org/10.1021/jacs.9b07105 https://www.ncbi.nlm.nih.gov/pubmed/31573191 https://www.proquest.com/docview/2299772212 https://www.proquest.com/docview/2335121162 |
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