Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination

• Published in: Journal of the American Chemical Society Vol. 143; no. 14; pp. 5349 - 5354
• Main Authors: Xu, Peng, López-Rojas, Priscila, Ritter, Tobias
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 14.04.2021; Amer Chemical Soc
• Subjects: Americans; benzoic acid; carboxylic acids; Chemistry; Chemistry, Multidisciplinary; crossing; ligands; metals; Physical Sciences; reaction chemistry; Science & Technology; temperature

Abundant aromatic carboxylic acids exist in great structural diversity from nature and synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic acids is realized mainly by transition-metal-catalyzed decarboxylative cross couplings. However, the high activation barr...