Cancer Risk After Radioactive Iodine Treatment for Hyperthyroidism A Systematic Review and Meta-analysis

• Published in: JAMA network open Vol. 4; no. 9; p. e2125072
• Main Authors: Shim, Sung Ryul, Kitahara, Cari M., Cha, Eun Shil, Kim, Seong-Jang, Bang, Ye Jin, Lee, Won Jin
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 01.09.2021
• Subjects: Adult; Breast cancer; Breast Neoplasms - epidemiology; Breast Neoplasms - etiology; Cancer therapies; Diabetes and Endocrinology; Female; Humans; Hyperthyroidism; Hyperthyroidism - radiotherapy; Incidence; Iodine; Iodine Radioisotopes - adverse effects; Male; Meta-analysis; Middle Aged; Mortality; Neoplasms, Radiation-Induced - epidemiology; Neoplasms, Radiation-Induced - etiology; Observational Studies as Topic; Odds Ratio; Online Only; Original Investigation; Proportional Hazards Models; Radiation; Thyroid cancer; Thyroid Neoplasms - epidemiology; Thyroid Neoplasms - etiology

Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health. To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism....