Harnessing the Noncanonical Keap1-Nrf2 Pathway for Human Cytomegalovirus Control

• Published in: Journal of virology Vol. 97; no. 4; p. e0016023
• Main Authors: Ghosh, Ayan K., Su, Yu-Pin, Forman, Michael, Keyes, Robert F., Smith, Brian C., Hu, Xin, Ferrer, Marc, Arav-Boger, Ravit
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 27.04.2023
• Subjects: Antimicrobial Chemotherapy; Antioxidant Response Elements - drug effects; Antiviral Agents - pharmacology; Cell Line; Cellular Response to Infection; Cytomegalovirus - drug effects; Cytomegalovirus - physiology; Cytomegalovirus Infections - prevention & control; Cytomegalovirus Infections - virology; Humans; Phosphorylation - drug effects; Transcription, Genetic - drug effects; Virus Replication; ARP101; SQSTM1/p62; p62-Keap1-Nrf2; human cytomegalovirus; noncanonical Keap1-Nrf2 pathway; antioxidant response element

Antiviral treatment for human cytomegalovirus (HCMV) is limited and suffers from the selection of drug-resistant viruses. Several cellular pathways have been shown to modulate HCMV replication. Host-derived cellular pathways can provide an unfavorable environment for virus replication. These pathway...