Pushing boundaries: mechanisms enabling bacterial pathogens to spread between cells

• Published in: Infection and immunity Vol. 92; no. 9; p. e0052423
• Main Authors: Raab, Julie E., Hamilton, Desmond J., Harju, Tucker B., Huynh, Thao N., Russo, Brian C.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 10.09.2024
• Subjects: Actin Cytoskeleton - metabolism; Animals; Bacteria - metabolism; Bacteria - pathogenicity; Bacterial Infections - microbiology; Cell Membrane - metabolism; Epithelial Cells - microbiology; Host-Microbial Interactions; Host-Pathogen Interactions; Humans; Minireview; Special Section: Minireviews from Early-Career Investigators; Vacuoles - microbiology; actin; Listeria; intercellular spread; Burkholderia; Rickettsia; Shigella; protrusions

For multiple intracellular bacterial pathogens, the ability to spread directly into adjacent epithelial cells is an essential step for disease in humans. For pathogens such as , , , and , this intercellular movement frequently requires the pathogens to manipulate the host actin cytoskeleton and defo...