Epitope(s) involving amino acids of the fusion loop of Japanese encephalitis virus envelope protein is(are) important to elicit protective immunity

• Published in: Journal of virology Vol. 98; no. 4; p. e0177323
• Main Authors: Fan, Yi-Chin, Chen, Jo-Mei, Chen, Yi-Ying, Ke, Yuan-Dun, Chang, Gwong-Jen J., Chiou, Shyan-Song
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 16.04.2024
• Subjects: Vaccines and Antiviral Agents; Virology; Japanese encephalitis virus; fusion loop

Introduction of mutations into the fusion loop is one potential strategy for generating safe dengue and Zika vaccines by reducing the risk of severe dengue following subsequent infections, and for constructing live-attenuated vaccine candidates against newly emerging Japanese encephalitis virus (JEV...