Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies

• Published in: Journal of virology Vol. 95; no. 3
• Main Authors: Fenwick, Craig, Croxatto, Antony, Coste, Alix T., Pojer, Florence, André, Cyril, Pellaton, Céline, Farina, Alex, Campos, Jérémy, Hacker, David, Lau, Kelvin, Bosch, Berend-Jan, Gonseth Nussle, Semira, Bochud, Murielle, D’Acremont, Valerie, Trono, Didier, Greub, Gilbert, Pantaleo, Giuseppe
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 13.01.2021
• Subjects: Antibodies, Viral - blood; Coronavirus Nucleocapsid Proteins - immunology; COVID-19 - blood; COVID-19 - epidemiology; COVID-19 - immunology; Female; Humans; Immunoassay; Immunoglobulin A - blood; Immunoglobulin G - blood; Male; Pathogenesis and Immunity; Phosphoproteins - immunology; Protein Multimerization; SARS-CoV-2 - immunology; Sensitivity and Specificity; Seroepidemiologic Studies; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Spotlight; Switzerland - epidemiology; Time Factors; Switzerland; SARS-CoV-2; S protein trimer; serology

In the present study, we have determined SARS-CoV-2-specific antibody responses in sera of acute and postinfection phase subjects. Our results indicate that antibody responses against viral S and N proteins were equally sensitive in the acute phase of infection, but that responses against N appear t...