Pharmacokinetics and Safety of Omadacycline in Subjects with Impaired Renal Function

• Published in: Antimicrobial agents and chemotherapy Vol. 62; no. 2
• Main Authors: Berg, Jolene K., Tzanis, Evan, Garrity-Ryan, Lynne, Bai, Stephen, Chitra, Surya, Manley, Amy, Villano, Stephen
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.02.2018
• Subjects: Anti-Bacterial Agents; Pharmacology; Renal Insufficiency; Tetracyclines; dose adjustment; omadacycline; renal impairment

Many antibiotics require dose adjustments in patients with renal impairment and/or in those undergoing hemodialysis. Omadacycline, the first aminomethylcycline antibiotic in late-stage clinical development, displays activity against a broad spectrum of bacterial pathogens, including drug-resistant s...