Mass Balance and Drug Interaction Potential of Intravenous Eravacycline Administered to Healthy Subjects

Eravacycline is a novel, fully synthetic fluorocycline that is approved for the treatment of complicated intra-abdominal infections (cIAI) in adult patients. We report results from three studies in healthy subjects that investigated the distribution, metabolism, and excretion of intravenous (i.v.) e...

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Bibliographic Details
Published inAntimicrobial agents and chemotherapy Vol. 63; no. 3
Main Authors Newman, Joseph V., Zhou, Jian, Izmailyan, Sergey, Tsai, Larry
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.03.2019
Subjects
Adult
Anti-Bacterial Agents
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - pharmacology
Cytochrome P-450 CYP3A - metabolism
Cytochrome P-450 CYP3A Inducers - pharmacology
Cytochrome P-450 CYP3A Inhibitors - pharmacology
Drug Interactions
Female
Healthy Volunteers
Humans
Itraconazole - pharmacology
Male
Middle Aged
Pharmacology
Rifampin - pharmacology
Tetracyclines
Tetracyclines - adverse effects
Tetracyclines - pharmacokinetics
Tetracyclines - pharmacology
ADME
eravacycline
drug interaction
Online AccessGet full text
ISSN0066-4804
1098-6596
1098-6596
DOI10.1128/AAC.01810-18

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