Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects

• Published in: Antimicrobial agents and chemotherapy Vol. 63; no. 9
• Main Authors: Eckburg, Paul B., Lister, Troy, Walpole, Susannah, Keutzer, Tim, Utley, Luke, Tomayko, John, Kopp, Ellen, Farinola, Nicholas, Coleman, Scott
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2019
• Subjects: Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Clinical Therapeutics; SPR741; pharmacokinetics; potentiator; drug interaction

SPR741 is a novel polymyxin B derivative, with minimal intrinsic antibacterial activity and reduced nonclinical nephrotoxicity compared to levels with polymyxin B, that interacts with the outer membrane of Gram-negative bacteria, enhancing penetration of coadministered antibiotics. SPR741 is a novel...