A Novel Attenuated Enterovirus A71 Mutant with VP1-V238A,K244R Exhibits Reduced Efficiency of Cell Entry/Exit and Augmented Binding Affinity to Sulfated Glycans

• Published in: Journal of virology Vol. 95; no. 22; p. e0105521
• Main Authors: Meng, Tao, Wong, Sek-Man, Chua, Kaw-Bing
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 27.10.2021
• Subjects: Animals; Antibodies, Neutralizing; Antigens, Viral; Cell Line, Tumor; Chlorocebus aethiops; Enterovirus A, Human - pathogenicity; Enterovirus A, Human - physiology; Hand, Foot and Mouth Disease - virology; Humans; Mice; NIH 3T3 Cells; Vaccines and Antiviral Agents; Vero Cells; Virology; Virulence; Virus Internalization; Virus Replication; sulfated glycans; virulence determinants; virus entry/exit; cell-adapted mutants; enterovirus A71; virus dissemination; live attenuated vaccines

Enterovirus A71 (EV-A71) is one of the major etiological agents of hand, foot, and mouth disease (HFMD), and infection occasionally leads to fatal neurological complications in children. However, only inactivated whole-virus vaccines against EV-A71 are commercially available in Mainland China. Furth...