Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay

• Published in: Antimicrobial agents and chemotherapy Vol. 62; no. 12
• Main Authors: Wei, Xia-Fei, Gan, Chun-Yang, Cui, Jing, Luo, Ying-Ying, Cai, Xue-Fei, Yuan, Yi, Shen, Jing, Li, Zhi-Ying, Zhang, Wen-Lu, Long, Quan-Xin, Hu, Yuan, Chen, Juan, Tang, Ni, Guo, Haitao, Huang, Ai-Long, Hu, Jie-Li
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.12.2018
• Subjects: Antiviral Agents; Diterpenes; Gene Expression Regulation, Viral; Hepatitis B virus; Indoles; Protein Multimerization; Viral Core Proteins; split luciferase; hepatitis B virus; dimer; 20-deoxyingenol; core protein; Arbidol; compound screen; cell model

The capsid of the hepatitis B virus is an attractive antiviral target for developing therapies against chronic hepatitis B infection. Currently available core protein allosteric modulators (CpAMs) mainly affect one of the two major types of protein-protein interactions involved in the process of cap...