The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission

• Published in: Antimicrobial agents and chemotherapy Vol. 60; no. 4; pp. 2108 - 2117
• Main Authors: Balaich, Jared N, Mathias, Derrick K, Torto, Baldwyn, Jackson, Bryan T, Tao, Dingyin, Ebrahimi, Babak, Tarimo, Brian B, Cheseto, Xavier, Foster, Woodbridge A, Dinglasan, Rhoel R
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.04.2016
• Subjects: Animals; Anopheles - parasitology; Antimalarials; Antimalarials - pharmacology; Artemisinins - pharmacology; Drug Resistance; Erythrocytes - drug effects; Erythrocytes - parasitology; Experimental Therapeutics; Female; Gene Expression; Genes, Reporter; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Humans; Inhibitory Concentration 50; Life Cycle Stages; Life Cycle Stages - drug effects; Malaria; Malaria - parasitology; Malaria - prevention & control; Malaria - transmission; Male; Mice; Plasmodium berghei; Plasmodium berghei - drug effects; Plasmodium berghei - growth & development; Plasmodium falciparum; Plasmodium falciparum - drug effects; Plasmodium falciparum - growth & development; Sesquiterpenes; Sesquiterpenes - pharmacology

Parthenin and parthenolide are natural products that are closely related in structure to artemisinin, which is also a sesquiterpene lactone (SQL) and one of the most important antimalarial drugs available. Parthenin, like artemisinin, has an effect onPlasmodiumblood stage development. We extended th...