Early Bactericidal Activity of Delpazolid (LCB01-0371) in Patients with Pulmonary Tuberculosis

• Published in: Antimicrobial agents and chemotherapy Vol. 66; no. 2; p. e0168421
• Main Authors: Kim, Ju Sang, Kim, Yong-hyun, Lee, Sang Haak, Kim, Yee Hyung, Kim, Jin-woo, Kang, Ji Young, Kim, Sung Kyoung, Kim, Seung Joon, Kang, Yun-Seong, Kim, Tae-hyung, Mok, Jeongha, Byun, Min Kwang, Park, Hye Jung, Joh, Joon-sung, Park, Yong Bum, Lim, Hyeong-Seok, Choi, Hongjo, Lee, Seung Heon, Kim, Hyejin, Yang, Jeongseong, Kim, Hyunji, Shen, Xianlin, Alsultan, Abdullah, Cho, InSook, Geiter, Lawrence, Shim, Tae Sun
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.02.2022
• Subjects: Adult; Aged; Antimicrobial Chemotherapy; Antitubercular Agents - therapeutic use; Drug Therapy, Combination; Editor's Pick; Experimental Therapeutics; Humans; Isoniazid - therapeutic use; Middle Aged; Mycobacterium tuberculosis; Oxazolidinones - pharmacokinetics; Oxazolidinones - therapeutic use; Pyrazinamide - therapeutic use; Sputum - microbiology; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - microbiology; Young Adult; Mycobacterium tuberculosis; experimental therapeutics; oxazolidinones; early bactericidal activity

Delpazolid, an oxazolidinone, has been studied in non-clinical studies of efficacy and toxicity and Phase 1 clinical studies. Delpazolid has in vitro activity against Gram-positive bacteria, including Mycobacterium tuberculosis . Delpazolid, an oxazolidinone, has been studied in non-clinical studies...