Sperm-Associated Antigen 9 Promotes Influenza A Virus-Induced Cell Death via the c-Jun N-Terminal Kinase Signaling Pathway

• Published in: mBio Vol. 13; no. 3; p. e0061522
• Main Authors: Gui, Rui, Zheng, Huabin, Ma, Liping, Liu, Renyi, Lin, Xian, Ke, Xianliang, Ye, Chang, Jian, Xiaoqin, Chen, Quanjiao
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 28.06.2022
• Subjects: c-Jun N-terminal kinase; cell death; DNA-dependent activator of interferon-regulatory factor; Immunology; JNK; PANoptosome; Research Article; Z-DNA binding protein 1; SPAG9; c-Jun N-terminal kinase; cell death; PANoptosome; Z-DNA binding protein 1; JNK; DNA-dependent activator of interferon-regulatory factor; sperm-associated antigen 9; influenza A virus

Upon influenza A virus (IAV) infection, DAI is activated, recruits downstream proteins to assemble a multiprotein platform (PANoptosome), and then triggers cell death. Until now, the protein composition and assembly mechanism of the PANoptosome during IAV infection had not been elucidated. Upon infl...