Single-Cell Landscape of Lungs Reveals Key Role of Neutrophil-Mediated Immunopathology during Lethal SARS-CoV-2 Infection

• Published in: Journal of virology Vol. 96; no. 9; p. e0003822
• Main Authors: Zheng, Xiao-Shuang, Wang, Qi, Min, Juan, Shen, Xu-Rui, Li, Qian, Zhao, Qiu-Chen, Wang, Xi, Jiang, Ren-Di, Geng, Rong, Chen, Ying, Zhu, Yan, Li, Bei, Zhang, Wei, Li, Ang, Xie, Ting-Ting, Liu, Mei-Qin, Cheng, Liang, Shi, Zheng-Li, Zhou, Peng
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 11.05.2022
• Subjects: Pathogenesis and Immunity; Virology; COVID-19; single-cell RNA sequencing; SARS-CoV-2; neutrophil; lung pathology

We demonstrated the single-cell landscape in lung and spleen upon SARS-CoV-2 infection in an acute severe disease mouse model that replicated human symptoms, including severe lung pathology and lymphopenia. Our comprehensive study revealed the key role of neutrophil-mediated lung immunopathology in...