Structure−Activity Relationships for Cytotoxic Ruthenium(II) Arene Complexes Containing N,N-, N,O-, and O,O-Chelating Ligands

• Published in: Journal of medicinal chemistry Vol. 49; no. 23; pp. 6858 - 6868
• Main Authors: Habtemariam, Abraha, Melchart, Michael, Fernández, Rafael, Parsons, Simon, Oswald, Iain D. H, Parkin, Andrew, Fabbiani, Francesca P. A, Davidson, James E, Dawson, Alice, Aird, Rhona E, Jodrell, Duncan I, Sadler, Peter J
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 16.11.2006
• Subjects: 2,2'-Dipyridyl - chemistry; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Benzene Derivatives - chemistry; Carboplatin - pharmacology; Cell Line, Tumor; Chelating Agents - chemistry; Cisplatin - pharmacology; Crystallography, X-Ray; Diamines - chemistry; Doxorubicin - pharmacology; Drug Screening Assays, Antitumor; Humans; Ligands; Molecular Structure; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Polycyclic Compounds - chemistry; Ruthenium; Structure-Activity Relationship

We report structure−activity relationships for organometallic RuII complexes of the type [(η6-arene)Ru(XY)Cl]Z, where XY is an N,N- (diamine), N,O- (e.g., amino acidate), or O,O- (e.g., β-diketonate) chelating ligand, the arene ranges from benzene derivatives to fused polycyclic hydrocarbons, and Z...