Lasso Peptide Benenodin‑1 Is a Thermally Actuated [1]Rotaxane Switch

• Published in: Journal of the American Chemical Society Vol. 139; no. 30; pp. 10403 - 10409
• Main Authors: Zong, Chuhan, Wu, Michelle J, Qin, Jason Z, Link, A. James
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.08.2017
• Subjects: amino acid substitution; Caulobacteraceae - chemistry; enzymes; heat; Kinetics; peptides; Peptides - chemistry; Peptides - genetics; Protein Conformation; Rotaxanes - chemistry; Temperature

Mechanically interlocked molecules that change their conformation in response to stimuli have been developed by synthetic chemists as building blocks for molecular machines. Here we describe a natural product, the lasso peptide benenodin-1, which exhibits conformational switching between two distinc...