Tracking Labile Copper Fluctuation In Vivo/Ex Vivo: Design and Application of a Ratiometric Near-Infrared Fluorophore Derived from 4‑Aminostyrene-Conjugated Boron Dipyrromethene

• Published in: Inorganic chemistry Vol. 60; no. 24; pp. 18567 - 18574
• Main Authors: Xu, Hongxia, Yao, Shankun, Chen, Yuncong, Zhang, Changli, Zhang, Shuren, Yuan, Hao, Chen, Zhongyan, Bai, Yang, Yang, Tao, Guo, Zijian, He, Weijiang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 20.12.2021
• Subjects: Animals; Boron Compounds - chemistry; Copper - chemistry; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; HEK293 Cells; Humans; Mice; Molecular Structure; Optical Imaging; Porphobilinogen - analogs & derivatives; Porphobilinogen - chemistry; Styrenes - chemistry

Specimen differences, tissue-dependent background fluorescence and scattering, and deviated specimen position and sensor concentration make optical imaging for labile copper fluctuation in animals questionable, and a signal comparison between specimens is infeasible. We proposed ratiometric optical...