HGF Induces Epithelial-to-Mesenchymal Transition by Modulating the Mammalian Hippo/MST2 and ISG15 Pathways

• Published in: Journal of proteome research Vol. 13; no. 6; pp. 2874 - 2886
• Main Authors: Farrell, Jennifer, Kelly, Ciara, Rauch, Jens, Kida, Katarzyna, García-Muñoz, Amaya, Monsefi, Naser, Turriziani, Benedetta, Doherty, Carolanne, Mehta, Jai P, Matallanas, David, Simpson, Jeremy C, Kolch, Walter, von Kriegsheim, Alex
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.06.2014
• Subjects: Animals; Cadherins - metabolism; Cell Adhesion; Dogs; Epithelial-Mesenchymal Transition; Hepatocyte Growth Factor - pharmacology; Hepatocyte Growth Factor - physiology; Integrins - metabolism; Madin Darby Canine Kidney Cells; Protein-Serine-Threonine Kinases - metabolism; Proteome - metabolism; Signal Transduction; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Ubiquitins - metabolism; Hippo-pathway; YAP1; ISG5; quantitative expression proteomics; Epithelial mesenchymal transition; SILAC

Epithelial to mesenchymal transition (EMT) is a fundamental cell differentiation/dedifferentiation process which is associated with dramatic morphological changes. Formerly polarized and immobile epithelial cells which form cell junctions and cobblestone-like cell sheets undergo a transition into hi...