Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects

• Published in: The American journal of psychiatry Vol. 163; no. 10; pp. 1784 - 1790
• Main Authors: Epstein, Jane, Pan, Hong, Kocsis, James H., Yang, Yihong, Butler, Tracy, Chusid, Jesse, Hochberg, Hilary, Murrough, James, Strohmayer, Erika, Stern, Emily, Silbersweig, David A.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Association 01.10.2006
• Subjects: Adult; Adult and adolescent clinical studies; Affect - physiology; Basal Ganglia - physiology; Basal Ganglia - physiopathology; Biological and medical sciences; Brain; Brain Mapping; Depression; Depressive Disorder - diagnosis; Depressive Disorder - physiopathology; Depressive Disorder - psychology; Design; Education; Female; Frontal Lobe - physiology; Frontal Lobe - physiopathology; Humans; Magnetic Resonance Imaging - statistics & numerical data; Male; Medical disorders; Medical sciences; Medical treatment; Middle Aged; Mood disorders; Motivation; Nucleus Accumbens - physiology; Nucleus Accumbens - physiopathology; Parahippocampal Gyrus - physiology; Parahippocampal Gyrus - physiopathology; Patients; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Reinforcement (Psychology); Reward; Verbal Behavior - physiology; Mood disorder; Human; Central nervous system; Depression; Basal ganglion; Corpus striatum; Comparative study; Encephalon

Objective: Most of the functional neuroimaging studies of depression have focused primarily on the resting state or responses to negatively valenced stimuli. However, depression consists not only of an accentuation of negative affective processing but of an inability to experience pleasure or positi...